The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer
Background: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas. Methods: TS...
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| Veröffentlicht in: | British journal of cancer 2014-04, Vol.110 (7), p.1744-1747 |
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| container_title | British journal of cancer |
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| creator | Downey, C L Simpkins, S A White, J Holliday, D L Jones, J L Jordan, L B Kulka, J Pollock, S Rajan, S S Thygesen, H H Hanby, A M Speirs, V |
| description | Background:
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
Methods:
TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
Results:
Tumours with ⩾49% stroma were associated with better survival in female (OS
P
=0.008, HR=0.2–0.7; RFS
P
=0.006, HR=0.1–0.6) and male breast cancer (OS
P
=0.005, HR=0.05–0.6; RFS
P
=0.01, HR=0.87–5.6), confirmed in multivariate analysis.
Conclusions:
High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR. |
| doi_str_mv | 10.1038/bjc.2014.69 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3974086</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3262872231</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-993569e1f7fdbf40dd3a9c55cffb4e13dc5cca204c9e1647daba5c799dde20903</originalsourceid><addsrcrecordid>eNptkc9qFTEYxYMo9lpduZeACIKda_7OTDZCKWqFgpu6DplMMs1lJhmTTMGd79A39EnM9F7bKq5C8v04Oec7ALzEaIsRbd93O70lCLNtLR6BDeaUVLglzWOwQQg1FRIEHYFnKe3KVaC2eQqOCOOsbWu8AeryysA5hsGHlJ2GyQ3eWaeV1wYGC_MyhSX--nmTcgyTglFlF6DzMJj1ZTAeRqPNnEOs5pBcdtcGdtGolOGtSHwOnlg1JvPicB6Db58-Xp6dVxdfP385O72oNGvqXAlBeS0Mto3tO8tQ31MlNOfa2o4ZTHvNtVYEMV2gmjW96hTXjRB9b0jJRY_Bh73uvHST6bXxOapRztFNKv6QQTn598S7KzmEa0lFw1BbF4G3B4EYvi8lnpxc0mYclTdhSRJzTDhniJKCvv4H3ZUt-RJvpXBLy35X6t2e0jGkFI29M4ORXKuTpTq5VidrUehXD_3fsX-6KsCbA6CSVqONZb0u3XMtR6St1xwney6VkR9MfGDuP__-Bh3ztDk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1511834542</pqid></control><display><type>article</type><title>The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer</title><source>MEDLINE</source><source>Nature</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Downey, C L ; Simpkins, S A ; White, J ; Holliday, D L ; Jones, J L ; Jordan, L B ; Kulka, J ; Pollock, S ; Rajan, S S ; Thygesen, H H ; Hanby, A M ; Speirs, V</creator><creatorcontrib>Downey, C L ; Simpkins, S A ; White, J ; Holliday, D L ; Jones, J L ; Jordan, L B ; Kulka, J ; Pollock, S ; Rajan, S S ; Thygesen, H H ; Hanby, A M ; Speirs, V</creatorcontrib><description>Background:
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
Methods:
TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
Results:
Tumours with ⩾49% stroma were associated with better survival in female (OS
P
=0.008, HR=0.2–0.7; RFS
P
=0.006, HR=0.1–0.6) and male breast cancer (OS
P
=0.005, HR=0.05–0.6; RFS
P
=0.01, HR=0.87–5.6), confirmed in multivariate analysis.
Conclusions:
High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.2014.69</identifier><identifier>PMID: 24548861</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/67/1347 ; 692/700/1750 ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Breast Neoplasms, Male - diagnosis ; Breast Neoplasms, Male - metabolism ; Breast Neoplasms, Male - mortality ; Breast Neoplasms, Male - pathology ; Cancer Research ; Drug Resistance ; Epidemiology ; Female ; Gynecology. Andrology. Obstetrics ; Humans ; Male ; Mammary gland diseases ; Medical sciences ; Middle Aged ; Molecular Medicine ; Oncology ; Predictive Value of Tests ; Prognosis ; Receptors, Estrogen - metabolism ; Short Communication ; Stromal Cells - pathology ; Survival Analysis ; Tumor Burden ; Tumors</subject><ispartof>British journal of cancer, 2014-04, Vol.110 (7), p.1744-1747</ispartof><rights>The Author(s) 2014</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Apr 1, 2014</rights><rights>Copyright © 2014 Cancer Research UK 2014 Cancer Research UK</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-993569e1f7fdbf40dd3a9c55cffb4e13dc5cca204c9e1647daba5c799dde20903</citedby><cites>FETCH-LOGICAL-c476t-993569e1f7fdbf40dd3a9c55cffb4e13dc5cca204c9e1647daba5c799dde20903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974086/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974086/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28502866$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24548861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Downey, C L</creatorcontrib><creatorcontrib>Simpkins, S A</creatorcontrib><creatorcontrib>White, J</creatorcontrib><creatorcontrib>Holliday, D L</creatorcontrib><creatorcontrib>Jones, J L</creatorcontrib><creatorcontrib>Jordan, L B</creatorcontrib><creatorcontrib>Kulka, J</creatorcontrib><creatorcontrib>Pollock, S</creatorcontrib><creatorcontrib>Rajan, S S</creatorcontrib><creatorcontrib>Thygesen, H H</creatorcontrib><creatorcontrib>Hanby, A M</creatorcontrib><creatorcontrib>Speirs, V</creatorcontrib><title>The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background:
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
Methods:
TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
Results:
Tumours with ⩾49% stroma were associated with better survival in female (OS
P
=0.008, HR=0.2–0.7; RFS
P
=0.006, HR=0.1–0.6) and male breast cancer (OS
P
=0.005, HR=0.05–0.6; RFS
P
=0.01, HR=0.87–5.6), confirmed in multivariate analysis.
Conclusions:
High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.</description><subject>692/699/67/1347</subject><subject>692/700/1750</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms, Male - diagnosis</subject><subject>Breast Neoplasms, Male - metabolism</subject><subject>Breast Neoplasms, Male - mortality</subject><subject>Breast Neoplasms, Male - pathology</subject><subject>Cancer Research</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Male</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Receptors, Estrogen - metabolism</subject><subject>Short Communication</subject><subject>Stromal Cells - pathology</subject><subject>Survival Analysis</subject><subject>Tumor Burden</subject><subject>Tumors</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptkc9qFTEYxYMo9lpduZeACIKda_7OTDZCKWqFgpu6DplMMs1lJhmTTMGd79A39EnM9F7bKq5C8v04Oec7ALzEaIsRbd93O70lCLNtLR6BDeaUVLglzWOwQQg1FRIEHYFnKe3KVaC2eQqOCOOsbWu8AeryysA5hsGHlJ2GyQ3eWaeV1wYGC_MyhSX--nmTcgyTglFlF6DzMJj1ZTAeRqPNnEOs5pBcdtcGdtGolOGtSHwOnlg1JvPicB6Db58-Xp6dVxdfP385O72oNGvqXAlBeS0Mto3tO8tQ31MlNOfa2o4ZTHvNtVYEMV2gmjW96hTXjRB9b0jJRY_Bh73uvHST6bXxOapRztFNKv6QQTn598S7KzmEa0lFw1BbF4G3B4EYvi8lnpxc0mYclTdhSRJzTDhniJKCvv4H3ZUt-RJvpXBLy35X6t2e0jGkFI29M4ORXKuTpTq5VidrUehXD_3fsX-6KsCbA6CSVqONZb0u3XMtR6St1xwney6VkR9MfGDuP__-Bh3ztDk</recordid><startdate>20140402</startdate><enddate>20140402</enddate><creator>Downey, C L</creator><creator>Simpkins, S A</creator><creator>White, J</creator><creator>Holliday, D L</creator><creator>Jones, J L</creator><creator>Jordan, L B</creator><creator>Kulka, J</creator><creator>Pollock, S</creator><creator>Rajan, S S</creator><creator>Thygesen, H H</creator><creator>Hanby, A M</creator><creator>Speirs, V</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140402</creationdate><title>The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer</title><author>Downey, C L ; Simpkins, S A ; White, J ; Holliday, D L ; Jones, J L ; Jordan, L B ; Kulka, J ; Pollock, S ; Rajan, S S ; Thygesen, H H ; Hanby, A M ; Speirs, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-993569e1f7fdbf40dd3a9c55cffb4e13dc5cca204c9e1647daba5c799dde20903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/699/67/1347</topic><topic>692/700/1750</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms, Male - diagnosis</topic><topic>Breast Neoplasms, Male - metabolism</topic><topic>Breast Neoplasms, Male - mortality</topic><topic>Breast Neoplasms, Male - pathology</topic><topic>Cancer Research</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Male</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Receptors, Estrogen - metabolism</topic><topic>Short Communication</topic><topic>Stromal Cells - pathology</topic><topic>Survival Analysis</topic><topic>Tumor Burden</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Downey, C L</creatorcontrib><creatorcontrib>Simpkins, S A</creatorcontrib><creatorcontrib>White, J</creatorcontrib><creatorcontrib>Holliday, D L</creatorcontrib><creatorcontrib>Jones, J L</creatorcontrib><creatorcontrib>Jordan, L B</creatorcontrib><creatorcontrib>Kulka, J</creatorcontrib><creatorcontrib>Pollock, S</creatorcontrib><creatorcontrib>Rajan, S S</creatorcontrib><creatorcontrib>Thygesen, H H</creatorcontrib><creatorcontrib>Hanby, A M</creatorcontrib><creatorcontrib>Speirs, V</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Downey, C L</au><au>Simpkins, S A</au><au>White, J</au><au>Holliday, D L</au><au>Jones, J L</au><au>Jordan, L B</au><au>Kulka, J</au><au>Pollock, S</au><au>Rajan, S S</au><au>Thygesen, H H</au><au>Hanby, A M</au><au>Speirs, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2014-04-02</date><risdate>2014</risdate><volume>110</volume><issue>7</issue><spage>1744</spage><epage>1747</epage><pages>1744-1747</pages><issn>0007-0920</issn><eissn>1532-1827</eissn><coden>BJCAAI</coden><abstract>Background:
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
Methods:
TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
Results:
Tumours with ⩾49% stroma were associated with better survival in female (OS
P
=0.008, HR=0.2–0.7; RFS
P
=0.006, HR=0.1–0.6) and male breast cancer (OS
P
=0.005, HR=0.05–0.6; RFS
P
=0.01, HR=0.87–5.6), confirmed in multivariate analysis.
Conclusions:
High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24548861</pmid><doi>10.1038/bjc.2014.69</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | 692/699/67/1347 692/700/1750 Adult Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms, Male - diagnosis Breast Neoplasms, Male - metabolism Breast Neoplasms, Male - mortality Breast Neoplasms, Male - pathology Cancer Research Drug Resistance Epidemiology Female Gynecology. Andrology. Obstetrics Humans Male Mammary gland diseases Medical sciences Middle Aged Molecular Medicine Oncology Predictive Value of Tests Prognosis Receptors, Estrogen - metabolism Short Communication Stromal Cells - pathology Survival Analysis Tumor Burden Tumors |
| title | The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer |
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