The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer
Background: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas. Methods: TS...
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Veröffentlicht in: | British journal of cancer 2014-04, Vol.110 (7), p.1744-1747 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Background:
A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas.
Methods:
TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed.
Results:
Tumours with ⩾49% stroma were associated with better survival in female (OS
P
=0.008, HR=0.2–0.7; RFS
P
=0.006, HR=0.1–0.6) and male breast cancer (OS
P
=0.005, HR=0.05–0.6; RFS
P
=0.01, HR=0.87–5.6), confirmed in multivariate analysis.
Conclusions:
High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR. |
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ISSN: | 0007-0920 1532-1827 |
DOI: | 10.1038/bjc.2014.69 |