The prognostic significance of tumour–stroma ratio in oestrogen receptor-positive breast cancer

Background: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas. Methods: TS...

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Veröffentlicht in:British journal of cancer 2014-04, Vol.110 (7), p.1744-1747
Hauptverfasser: Downey, C L, Simpkins, S A, White, J, Holliday, D L, Jones, J L, Jordan, L B, Kulka, J, Pollock, S, Rajan, S S, Thygesen, H H, Hanby, A M, Speirs, V
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Sprache:eng
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Zusammenfassung:Background: A high percentage of stroma predicts poor survival in triple-negative breast cancers but is diminished in studies of unselected cases. We determined the prognostic significance of tumour–stroma ratio (TSR) in oestrogen receptor (ER)-positive male and female breast carcinomas. Methods: TSR was measured in haematoxylin and eosin-stained tissue sections (118 female and 62 male). Relationship of TSR (cutoff 49%) to overall survival (OS) and relapse-free survival (RFS) was analysed. Results: Tumours with ⩾49% stroma were associated with better survival in female (OS P =0.008, HR=0.2–0.7; RFS P =0.006, HR=0.1–0.6) and male breast cancer (OS P =0.005, HR=0.05–0.6; RFS P =0.01, HR=0.87–5.6), confirmed in multivariate analysis. Conclusions: High stromal content was related to better survival in ER-positive breast cancers across both genders, contrasting data in triple-negative breast cancer and highlighting the importance of considering ER status when interpreting the prognostic value of TSR.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2014.69