Circadian timekeeping and output mechanisms in animals

Highlights • Work on circadian period determination and output gene regulation are reviewed. • Clock protein glycosylation, ubiquitylation and translation influence 24 hours periodicity. • Whole genome approaches reveal novel features of clock-controlled transcription. • Rhythms in post-transcriptio...

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Veröffentlicht in:Current opinion in neurobiology 2013-10, Vol.23 (5), p.724-731
Hauptverfasser: Hardin, Paul E, Panda, Satchidananda
Format: Artikel
Sprache:eng
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Zusammenfassung:Highlights • Work on circadian period determination and output gene regulation are reviewed. • Clock protein glycosylation, ubiquitylation and translation influence 24 hours periodicity. • Whole genome approaches reveal novel features of clock-controlled transcription. • Rhythms in post-transcriptional regulators imply more pervasive circadian expression.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2013.02.018