An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1

Broadly HIV-1-neutralizing antibodies (BnAbs) display one or more unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreactivity, and high levels of somatic mutations. These shared characteristics suggest that BnAb development might be limited by immune tol...

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Veröffentlicht in:	The Journal of clinical investigation 2014-04, Vol.124 (4), p.1835-1843
Hauptverfasser:	Bonsignori, Mattia, Wiehe, Kevin, Grimm, Sebastian K, Lynch, Rebecca, Yang, Guang, Kozink, Daniel M, Perrin, Florence, Cooper, Abby J, Hwang, Kwan-Ki, Chen, Xi, Liu, Mengfei, McKee, Krisha, Parks, Robert J, Eudailey, Joshua, Wang, Minyue, Clowse, Megan, Criscione-Schreiber, Lisa G, Moody, M Anthony, Ackerman, Margaret E, Boyd, Scott D, Gao, Feng, Kelsoe, Garnett, Verkoczy, Laurent, Tomaras, Georgia D, Liao, Hua-Xin, Kepler, Thomas B, Montefiori, David C, Mascola, John R, Haynes, Barton F
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adult AIDS Amino Acid Sequence Antibodies, Antinuclear - blood Antibodies, Antinuclear - chemistry Antibodies, Antinuclear - genetics Antibodies, Neutralizing - blood Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Autoantibodies Autoantibodies - blood Autoantibodies - chemistry Autoantibodies - genetics Autoimmune diseases B-Lymphocytes - immunology Base Sequence Binding sites Biomedical research Cell culture DNA - genetics Enzymes Female Gene amplification Genetic aspects HIV Antibodies - blood HIV Antibodies - chemistry HIV Antibodies - genetics HIV Envelope Protein gp120 - chemistry HIV Envelope Protein gp120 - immunology HIV infection HIV Infections - complications HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Human immunodeficiency virus 1 Humans Hypotheses Identification and classification Immunologic Memory Immunological tolerance Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - immunology Models, Molecular Molecular Sequence Data Multiprotein Complexes - chemistry Mutation Physiological aspects Plasma Protein Conformation Proteins Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid Systemic lupus erythematosus Vaccines Viral Load
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Zusammenfassung:	Broadly HIV-1-neutralizing antibodies (BnAbs) display one or more unusual traits, including a long heavy chain complementarity-determining region 3 (HCDR3), polyreactivity, and high levels of somatic mutations. These shared characteristics suggest that BnAb development might be limited by immune tolerance controls. It has been postulated that HIV-1-infected individuals with autoimmune disease and defective immune tolerance mechanisms may produce BnAbs more readily than those without autoimmune diseases. In this study, we identified an HIV-1-infected individual with SLE who exhibited controlled viral load (
ISSN:	0021-9738 1558-8238
DOI:	10.1172/JCI73441