Host defenses against bacterial lower respiratory tract infection

Highlights ► Pattern recognition receptors respond to a wide variety of bacterial pathogens in the lung. ► IL-23 stimulates innate production of IL-17 and IL-22 which increase lung defenses. ► CD4+ T cell subtypes play a critical role in orchestrating lung immunity. ► Lung epithelia can modulate B c...

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Veröffentlicht in:	Current opinion in immunology 2012-08, Vol.24 (4), p.424-430
Hauptverfasser:	Eddens, Taylor, Kolls, Jay K
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology B-Lymphocytes - immunology CD4-Positive T-Lymphocytes - immunology Cytokines - metabolism Humans Immunity, Innate - physiology Immunity, Mucosal - physiology Pneumonia, Bacterial - immunology Respiratory System - microbiology Signal Transduction - physiology
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Beschreibung
Zusammenfassung:	Highlights ► Pattern recognition receptors respond to a wide variety of bacterial pathogens in the lung. ► IL-23 stimulates innate production of IL-17 and IL-22 which increase lung defenses. ► CD4+ T cell subtypes play a critical role in orchestrating lung immunity. ► Lung epithelia can modulate B cell maturation through BAFF and APRIL.
ISSN:	0952-7915 1879-0372
DOI:	10.1016/j.coi.2012.07.005