Clinical Features and Racial/Ethnic Differences Among the 3020 Participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) Trial

This study examined the baseline characteristics, racial/ethnic differences, and geographic differences among participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) study. The SPS3 trial enrolled patients who experienced a symptomatic small subcortical stroke (lacunar stroke) w...

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Veröffentlicht in:	Journal of stroke and cerebrovascular diseases 2013-08, Vol.22 (6), p.764-774
Hauptverfasser:	White, Carole L., RN, PhD, Szychowski, Jeff M., PhD, Roldan, Ana, MD, Benavente, Marie-France, BScN, Pretell, Edwin J., MD, Del Brutto, Oscar H., MD, Kase, Carlos S., MD, Arauz, Antonio, MD, PhD, Meyer, Brett C., MD, Meissner, Irene, MD, Demaerschalk, Bart M., MD, McClure, Leslie A., PhD, Coffey, Christopher S., PhD, Pearce, Lesly A., MS, Conwit, Robin, MD, Irby, Lisa H., BA, Peri, Kalyani, MS, Pergola, Pablo E., MD, PhD, Hart, Robert G., MD, Benavente, Oscar R., MD
Format:	Artikel
Sprache:	eng
Schlagworte:	African Americans Aged Antihypertensive Agents - administration & dosage antiplatelet Aspirin - administration & dosage blood pressure Blood Pressure - drug effects Cardiovascular Chi-Square Distribution clinical trial cognition Continental Population Groups Diabetes Mellitus - ethnology Drug Administration Schedule Drug Therapy, Combination Ethnic Groups European Continental Ancestry Group Female Hispanic Americans Humans Hypertension - ethnology Lacunar Magnetic Resonance Imaging Male Middle Aged Neurology North America - epidemiology Platelet Aggregation Inhibitors - administration & dosage Prevalence prevention Risk Factors Secondary Prevention - methods small vessel disease Smoking - adverse effects Smoking - ethnology South America - epidemiology Spain - epidemiology Stroke - diagnosis Stroke - ethnology Stroke - physiopathology Stroke - prevention & control Ticlopidine - administration & dosage Ticlopidine - analogs & derivatives Time Factors Treatment Outcome
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Zusammenfassung:	This study examined the baseline characteristics, racial/ethnic differences, and geographic differences among participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) study. The SPS3 trial enrolled patients who experienced a symptomatic small subcortical stroke (lacunar stroke) within the previous 6 months and an eligible lesion on detected on magnetic resonance imaging. The patients were randomized, in a factorial design, to antiplatelet therapy (aspirin 325 mg daily plus clopidogrel 75 mg daily vs aspirin 325 mg daily plus placebo) and to one of two levels of systolic blood pressure targets (“intensive” [
ISSN:	1052-3057 1532-8511
DOI:	10.1016/j.jstrokecerebrovasdis.2012.03.002