Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial

Purged versus non-purged peripheral blood stem-cell transplantation for high-risk neuroblastoma (COG A3973): a randomised phase 3 trial

Summary Background Myeloablative chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been shown to improve outcome for patients with high-risk neuroblastoma. Currently, peripheral blood stem cells (PBSC) are infused after myeloablative therapy, but the effect o...

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Veröffentlicht in:The lancet oncology 2013-09, Vol.14 (10), p.999-1008
Hauptverfasser: Kreissman, Susan G, Prof Dr, Seeger, Robert C, Prof, Matthay, Katherine K, Prof, London, Wendy B, PhD, Sposto, Richard, Prof, Grupp, Stephan A, Prof, Haas-Kogan, Daphne A, Prof, LaQuaglia, Michael P, Prof, Yu, Alice L, Prof, Diller, Lisa, Prof, Buxton, Allen, MS, Park, Julie R, Prof, Cohn, Susan L, Prof, Maris, John M, Prof, Reynolds, C Patrick, Prof, Villablanca, Judith G, Prof
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Antigens
Bone marrow
Cancer therapies
Chemotherapy
Child
Child, Preschool
Children & youth
Disease-Free Survival
Hematology, Oncology and Palliative Medicine
Histology
Humans
Immunomagnetic Separation
Infant
Laboratories
Monoclonal antibodies
Neuroblastoma
Neuroblastoma - mortality
Neuroblastoma - therapy
Neutrophils
Oncology
Peripheral Blood Stem Cell Transplantation - adverse effects
Peripheral Blood Stem Cell Transplantation - methods
Risk
Toxicity
Transplants & implants
Tumors
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Zusammenfassung:Summary Background Myeloablative chemoradiotherapy and immunomagnetically purged autologous bone marrow transplantation has been shown to improve outcome for patients with high-risk neuroblastoma. Currently, peripheral blood stem cells (PBSC) are infused after myeloablative therapy, but the effect of purging is unknown. We did a randomised study of tumour-selective PBSC purging in stem-cell transplantation for patients with high-risk neuroblastoma. Methods Between March 16, 2001, and Feb 24, 2006, children and young adults (
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(13)70309-7