Visualizing epigenetics: Current advances and advantages in HDAC PET imaging techniques

Highlights • Invasive measurements of epigenetics can be conceptually adapted for human brain imaging. • Noninvasive measurements of HDAC expression and function are being developed. • Functional consequences of epigenetic modulation can be imaged with PET and fMRI.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-04, Vol.264, p.186-197
Hauptverfasser:	Wang, C, Schroeder, F.A, Hooker, J.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain - diagnostic imaging Brain - enzymology Epigenomics - methods Histone Deacetylases - analysis Histone Deacetylases - metabolism Humans Neurology Positron-Emission Tomography - methods
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Highlights • Invasive measurements of epigenetics can be conceptually adapted for human brain imaging. • Noninvasive measurements of HDAC expression and function are being developed. • Functional consequences of epigenetic modulation can be imaged with PET and fMRI.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.09.018