Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings
•Multi-frequency axial scanning ultrasonometer acquires wave propagation profiles along the proximal tibia.•Diagnostic parameters derived from the profiles at different frequencies were compared with DXA data in postmenopausal women.•Integral linear classifier provided 87.7% sensitivity and 63.2% sp...
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| Veröffentlicht in: | Ultrasonics 2014-07, Vol.54 (5), p.1170-1177 |
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| creator | Egorov, Vladimir Tatarinov, Alexey Sarvazyan, Noune Wood, Randee Magidenko, Leonid Amin, Shreyasee Khosla, Sundeep Ruh, Richard J. Ruh, Jennifer M. Sarvazyan, Armen |
| description | •Multi-frequency axial scanning ultrasonometer acquires wave propagation profiles along the proximal tibia.•Diagnostic parameters derived from the profiles at different frequencies were compared with DXA data in postmenopausal women.•Integral linear classifier provided 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis.
The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the “gold standard” for the assessment of osteoporosis (T-score |
| doi_str_mv | 10.1016/j.ultras.2013.08.017 |
| format | Article |
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The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the “gold standard” for the assessment of osteoporosis (T-score<−2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS’s capability to detect osteoporosis in postmenopausal women.</description><identifier>ISSN: 0041-624X</identifier><identifier>EISSN: 1874-9968</identifier><identifier>DOI: 10.1016/j.ultras.2013.08.017</identifier><identifier>PMID: 24070826</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Absorptiometry, Photon ; Aged ; Aged, 80 and over ; Assessments ; Axial scanning ; Body Mass Index ; Bone Density ; Bone Diseases, Metabolic - diagnostic imaging ; Bone quantitative ultrasound ; Bones ; Devices ; Equipment Design ; Female ; Humans ; Middle Aged ; Multi-frequency ; Operators ; Osteoporosis ; Osteoporosis, Postmenopausal - diagnostic imaging ; Receivers ; Sensitivity and Specificity ; Ultrasonography - instrumentation ; Wave propagation ; Wave propagation parameters</subject><ispartof>Ultrasonics, 2014-07, Vol.54 (5), p.1170-1177</ispartof><rights>2013 Elsevier B.V.</rights><rights>Copyright © 2013 Elsevier B.V. All rights reserved.</rights><rights>2013 Elsevier B.V. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-5ee2dc124dced9312695101e74fe5811bcc5160b5c246ae8a6e0c9e598b19c963</citedby><cites>FETCH-LOGICAL-c496t-5ee2dc124dced9312695101e74fe5811bcc5160b5c246ae8a6e0c9e598b19c963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultras.2013.08.017$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24070826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Egorov, Vladimir</creatorcontrib><creatorcontrib>Tatarinov, Alexey</creatorcontrib><creatorcontrib>Sarvazyan, Noune</creatorcontrib><creatorcontrib>Wood, Randee</creatorcontrib><creatorcontrib>Magidenko, Leonid</creatorcontrib><creatorcontrib>Amin, Shreyasee</creatorcontrib><creatorcontrib>Khosla, Sundeep</creatorcontrib><creatorcontrib>Ruh, Richard J.</creatorcontrib><creatorcontrib>Ruh, Jennifer M.</creatorcontrib><creatorcontrib>Sarvazyan, Armen</creatorcontrib><title>Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings</title><title>Ultrasonics</title><addtitle>Ultrasonics</addtitle><description>•Multi-frequency axial scanning ultrasonometer acquires wave propagation profiles along the proximal tibia.•Diagnostic parameters derived from the profiles at different frequencies were compared with DXA data in postmenopausal women.•Integral linear classifier provided 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis.
The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the “gold standard” for the assessment of osteoporosis (T-score<−2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS’s capability to detect osteoporosis in postmenopausal women.</description><subject>Absorptiometry, Photon</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Assessments</subject><subject>Axial scanning</subject><subject>Body Mass Index</subject><subject>Bone Density</subject><subject>Bone Diseases, Metabolic - diagnostic imaging</subject><subject>Bone quantitative ultrasound</subject><subject>Bones</subject><subject>Devices</subject><subject>Equipment Design</subject><subject>Female</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Multi-frequency</subject><subject>Operators</subject><subject>Osteoporosis</subject><subject>Osteoporosis, Postmenopausal - diagnostic imaging</subject><subject>Receivers</subject><subject>Sensitivity and Specificity</subject><subject>Ultrasonography - instrumentation</subject><subject>Wave propagation</subject><subject>Wave propagation parameters</subject><issn>0041-624X</issn><issn>1874-9968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1v1DAQtRCILoV_gFCOXJJ6EseJOSChFaWVKvUCEjfLcSbFq8QOdtLSS397Z9lS4AIny_a8j3mPsdfAC-AgT3bFOi7RpKLkUBW8LTg0T9gG2kbkSsn2KdtwLiCXpfh6xF6ktOMcRAvVc3ZUCt7wtpQbdneZFgxziCG5lPW4oF1c8Jnz2RzSMqEPs1mTGbObQJdsTc5fZeaHoxdS92lyKe0BE7lx-RDx-4re3mZd8JgdHAZP0AXju2w7Ou8sQQfneyJKL9mzwYwJXz2cx-zL6cfP27P84vLT-fbDRW6FkkteI5a9hVL0FntVQSlVTSFgIwasW4DO2hok72pbCmmwNRK5VVirtgNllayO2fsD77x2ExKLJ2OjnqObTLzVwTj994933_RVuNYVCVFURPD2gSAG2jAtmha3OI7GY1iThroiQ6L5qfW_USjrWoHiNCoOo5byTxGHR0fA9b5lvdOHDPW-Zc1bTS0T7M2f2zyCftX6e12kTK8dRp2so1qwd5EK1n1w_1a4B50qwB4</recordid><startdate>20140701</startdate><enddate>20140701</enddate><creator>Egorov, Vladimir</creator><creator>Tatarinov, Alexey</creator><creator>Sarvazyan, Noune</creator><creator>Wood, Randee</creator><creator>Magidenko, Leonid</creator><creator>Amin, Shreyasee</creator><creator>Khosla, Sundeep</creator><creator>Ruh, Richard J.</creator><creator>Ruh, Jennifer M.</creator><creator>Sarvazyan, Armen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7SP</scope><scope>7U5</scope><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>5PM</scope></search><sort><creationdate>20140701</creationdate><title>Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings</title><author>Egorov, Vladimir ; Tatarinov, Alexey ; Sarvazyan, Noune ; Wood, Randee ; Magidenko, Leonid ; Amin, Shreyasee ; Khosla, Sundeep ; Ruh, Richard J. ; Ruh, Jennifer M. ; Sarvazyan, Armen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c496t-5ee2dc124dced9312695101e74fe5811bcc5160b5c246ae8a6e0c9e598b19c963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorptiometry, Photon</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Assessments</topic><topic>Axial scanning</topic><topic>Body Mass Index</topic><topic>Bone Density</topic><topic>Bone Diseases, Metabolic - diagnostic imaging</topic><topic>Bone quantitative ultrasound</topic><topic>Bones</topic><topic>Devices</topic><topic>Equipment Design</topic><topic>Female</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Multi-frequency</topic><topic>Operators</topic><topic>Osteoporosis</topic><topic>Osteoporosis, Postmenopausal - diagnostic imaging</topic><topic>Receivers</topic><topic>Sensitivity and Specificity</topic><topic>Ultrasonography - instrumentation</topic><topic>Wave propagation</topic><topic>Wave propagation parameters</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Egorov, Vladimir</creatorcontrib><creatorcontrib>Tatarinov, Alexey</creatorcontrib><creatorcontrib>Sarvazyan, Noune</creatorcontrib><creatorcontrib>Wood, Randee</creatorcontrib><creatorcontrib>Magidenko, Leonid</creatorcontrib><creatorcontrib>Amin, Shreyasee</creatorcontrib><creatorcontrib>Khosla, Sundeep</creatorcontrib><creatorcontrib>Ruh, Richard J.</creatorcontrib><creatorcontrib>Ruh, Jennifer M.</creatorcontrib><creatorcontrib>Sarvazyan, Armen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Electronics & Communications Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ultrasonics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Egorov, Vladimir</au><au>Tatarinov, Alexey</au><au>Sarvazyan, Noune</au><au>Wood, Randee</au><au>Magidenko, Leonid</au><au>Amin, Shreyasee</au><au>Khosla, Sundeep</au><au>Ruh, Richard J.</au><au>Ruh, Jennifer M.</au><au>Sarvazyan, Armen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings</atitle><jtitle>Ultrasonics</jtitle><addtitle>Ultrasonics</addtitle><date>2014-07-01</date><risdate>2014</risdate><volume>54</volume><issue>5</issue><spage>1170</spage><epage>1177</epage><pages>1170-1177</pages><issn>0041-624X</issn><eissn>1874-9968</eissn><abstract>•Multi-frequency axial scanning ultrasonometer acquires wave propagation profiles along the proximal tibia.•Diagnostic parameters derived from the profiles at different frequencies were compared with DXA data in postmenopausal women.•Integral linear classifier provided 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis.
The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the “gold standard” for the assessment of osteoporosis (T-score<−2.5). BUSS wave parameters were studied in 331 postmenopausal women examined by 9 trained operators at 3 clinical sites with use of 3 devices. The efficiency of each BUSS parameter in osteoporosis detection was assessed using a receiver operating characteristic curve analysis. Area under the curve (AUC) for each of 10 parameters ranged from 58.1% to 70.2%. Using these parameters a linear classifier was derived which provided at its output 83.0% AUC, 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The results of this study confirm BUSS’s capability to detect osteoporosis in postmenopausal women.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>24070826</pmid><doi>10.1016/j.ultras.2013.08.017</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Ultrasonics, 2014-07, Vol.54 (5), p.1170-1177 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Absorptiometry, Photon Aged Aged, 80 and over Assessments Axial scanning Body Mass Index Bone Density Bone Diseases, Metabolic - diagnostic imaging Bone quantitative ultrasound Bones Devices Equipment Design Female Humans Middle Aged Multi-frequency Operators Osteoporosis Osteoporosis, Postmenopausal - diagnostic imaging Receivers Sensitivity and Specificity Ultrasonography - instrumentation Wave propagation Wave propagation parameters |
| title | Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings |
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