Osteoporosis detection in postmenopausal women using axial transmission multi-frequency bone ultrasonometer: Clinical findings

•Multi-frequency axial scanning ultrasonometer acquires wave propagation profiles along the proximal tibia.•Diagnostic parameters derived from the profiles at different frequencies were compared with DXA data in postmenopausal women.•Integral linear classifier provided 87.7% sensitivity and 63.2% specificity to DXA-identified osteoporosis. The objective of this study was to evaluate if the Bone UltraSonic Scanner (BUSS) can detect osteoporosis in postmenopausal women. BUSS is an axial transmission multi-frequency ultrasonometer for acquisition of wave propagation profiles along the proximal anterior tibia. We derived 10 diagnostically significant BUSS parameters that were then compared with the DXA spine T-score, which was used in this study as the “gold standard” for the assessment of osteoporosis (T-score