Drinking through the pain

A feature of abusive alcohol drinking has been modeled successfully in experiments with rats. The experiments show that changes in NMDA signaling in specific neural circuits accompany the transition to aversion-resistant drinking.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature neuroscience 2013-08, Vol.16 (8), p.987-988
Hauptverfasser:	Kash, Thomas L, Crabbe, John C
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2649/1662 Alcohol Deterrents - pharmacology Alcohol Drinking - physiopathology Alcohol use Alcoholism Animal Genetics and Genomics Animals Avoidance Learning - physiology Behavioral Sciences Biological Techniques Biomedicine Cerebral Cortex - physiopathology Cocaine Drug Resistance - physiology Male Methyl aspartate Nerve Tissue Proteins - physiology Neural circuitry Neurobiology Neuropsychology Neurosciences news-and-views Nucleus Accumbens - physiopathology Pain Physiology Prefrontal Cortex - physiopathology Psychological aspects Quinine - pharmacology Receptors, N-Methyl-D-Aspartate - physiology Rodents
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Beschreibung
Zusammenfassung:	A feature of abusive alcohol drinking has been modeled successfully in experiments with rats. The experiments show that changes in NMDA signaling in specific neural circuits accompany the transition to aversion-resistant drinking.
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn.3476