Efficacy and safety of sunitinib in elderly patients with metastatic renal cell carcinoma

Background: We retrospectively analyzed sunitinib outcome as a function of age in metastatic renal cell carcinoma (mRCC) patients. Methods: Data were pooled from 1059 patients in six trials. Kaplan–Meier estimates of progression-free survival (PFS) and overall survival (OS) were compared by log-rank...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of cancer 2014-03, Vol.110 (5), p.1125-1132
Hauptverfasser:	Hutson, T E, Bukowski, R M, Rini, B I, Gore, M E, Larkin, J M, Figlin, R A, Barrios, C H, Escudier, B, Lin, X, Fly, K, Martell, B, Matczak, E, Motzer, R J
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436/108 692/699/67/589/1588/1351 692/700/1518 692/700/565/1436 Adult Age Aged Aged, 80 and over Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cancer therapies Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - pathology Clinical Study Clinical trials Clinical Trials, Phase III as Topic Cytokines Disease-Free Survival Drug Resistance Epidemiology Female Growth factors Humans Indoles - adverse effects Indoles - therapeutic use Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Kidneys Male Medical sciences Metastasis Middle Aged Molecular Medicine Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Nephrology. Urinary tract diseases Oncology Prospective Studies Pyrroles - adverse effects Pyrroles - therapeutic use Randomized Controlled Trials as Topic Retrospective Studies Schedules Toxicity Treatment Outcome Tumors Tumors of the urinary system Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Background: We retrospectively analyzed sunitinib outcome as a function of age in metastatic renal cell carcinoma (mRCC) patients. Methods: Data were pooled from 1059 patients in six trials. Kaplan–Meier estimates of progression-free survival (PFS) and overall survival (OS) were compared by log-rank test between patients aged
ISSN:	0007-0920 1532-1827
DOI:	10.1038/bjc.2013.832