Sexual dimorphism in BDNF signaling after neonatal hypoxia–ischemia and treatment with necrostatin-1

Highlights • In both sexes, neonatal HI acutely increases BDNF levels in forebrain but not diencephalon. • In both sexes, HI decreases BDNF in forebrain and TrkB activation in diencephalon. • Only in female mice, neonatal HI increases p75ntr and truncated TrkB levels. • Only in male mice, nec-1 pres...

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Veröffentlicht in:	Neuroscience 2014-02, Vol.260, p.106-119
Hauptverfasser:	Chavez-Valdez, R, Martin, L.J, Razdan, S, Gauda, E.B, Northington, F.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Biological and medical sciences Brain-Derived Neurotrophic Factor - metabolism cortex Diencephalon - drug effects Diencephalon - metabolism estradiol Estradiol - analysis Female Fundamental and applied biological sciences. Psychology Hypoxia-Ischemia, Brain - drug therapy Hypoxia-Ischemia, Brain - metabolism Imidazoles - therapeutic use Indoles - therapeutic use Male Mice Mice, Inbred C57BL Neurology Neuroprotective Agents - therapeutic use p75ntr Parvalbumins - metabolism plasticity Prosencephalon - drug effects Prosencephalon - metabolism Receptors, Estrogen - metabolism Sex Factors thalamus truncated TrkB receptor Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • In both sexes, neonatal HI acutely increases BDNF levels in forebrain but not diencephalon. • In both sexes, HI decreases BDNF in forebrain and TrkB activation in diencephalon. • Only in female mice, neonatal HI increases p75ntr and truncated TrkB levels. • Only in male mice, nec-1 preserves BDNF levels and TrkB activation. • BDNF changes directly correlate with estrogen receptor α:β ratio.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.12.023