Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia
Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian re...
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| creator | Belen, Burcu Hismi, Burcu Ozturk Kocak, Ulker |
| description | Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis. |
| doi_str_mv | 10.1136/bcr-2014-203742 |
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However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.</description><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2014-203742</identifier><identifier>PMID: 24599434</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>12 months ; Anemia ; Anemia, Myelophthisic - diagnosis ; Anemia, Myelophthisic - etiology ; Anemia, Pernicious - complications ; Anemia, Pernicious - diagnosis ; Bone marrow ; Breastfeeding & lactation ; Dehydrogenases ; Diagnosis, Differential ; Granulocytes ; Hemoglobin ; Hepatomegaly - diagnosis ; Hepatomegaly - etiology ; Homocysteine ; Humans ; Infant ; Laboratories ; Leukemia ; Male ; Middle East ; Neutrophils ; Pancytopenia - diagnosis ; Pancytopenia - etiology ; Patients ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Refugee camps ; Refugees ; Socioeconomic factors ; Splenomegaly - diagnosis ; Splenomegaly - etiology ; Syria ; Thrombocytopenia ; Turkey ; Unusual Association of Diseases/Symptoms ; Uric acid</subject><ispartof>BMJ case reports, 2014-03, Vol.2014</ispartof><rights>2014 BMJ Publishing Group Ltd</rights><rights>Copyright: 2014 2014 BMJ Publishing Group Ltd</rights><rights>2014 BMJ Publishing Group Ltd 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948160/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3948160/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24599434$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belen, Burcu</creatorcontrib><creatorcontrib>Hismi, Burcu Ozturk</creatorcontrib><creatorcontrib>Kocak, Ulker</creatorcontrib><title>Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.</description><subject>12 months</subject><subject>Anemia</subject><subject>Anemia, Myelophthisic - diagnosis</subject><subject>Anemia, Myelophthisic - etiology</subject><subject>Anemia, Pernicious - complications</subject><subject>Anemia, Pernicious - diagnosis</subject><subject>Bone marrow</subject><subject>Breastfeeding & lactation</subject><subject>Dehydrogenases</subject><subject>Diagnosis, Differential</subject><subject>Granulocytes</subject><subject>Hemoglobin</subject><subject>Hepatomegaly - diagnosis</subject><subject>Hepatomegaly - etiology</subject><subject>Homocysteine</subject><subject>Humans</subject><subject>Infant</subject><subject>Laboratories</subject><subject>Leukemia</subject><subject>Male</subject><subject>Middle East</subject><subject>Neutrophils</subject><subject>Pancytopenia - diagnosis</subject><subject>Pancytopenia - etiology</subject><subject>Patients</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</subject><subject>Refugee camps</subject><subject>Refugees</subject><subject>Socioeconomic factors</subject><subject>Splenomegaly - diagnosis</subject><subject>Splenomegaly - etiology</subject><subject>Syria</subject><subject>Thrombocytopenia</subject><subject>Turkey</subject><subject>Unusual Association of Diseases/Symptoms</subject><subject>Uric acid</subject><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkkGL1TAUhYsgzjAza3cScCNitWmS18aFMA6OCgMuRsFduE1vXvNsk5qkb-if8jeaxxsHNYvkknv47gk5RfGUVq8pZZs3nQ5lXVGeN9bw-lFxShvRlI2svp8UFzHuqrwY5S1nT4qTmgspOeOnxa9b3GNAsrcJJuvIe1qTHo3VFp1eyZ1NA5khl8nP6Cy8IgPOkHycR3R-wi2MKwHXkxGXHx7DmobguxFilthIMjHdeXK7BguOBDTLFjHfGnApviVA9ABjJm2RJE96a0w245KFhMQEPxHQSy4PcMDJwnnx2MAY8eL-PCu-XX_4evWpvPny8fPV5U3ZMSHqkupem4aLjZaoTdUBNlS2FLkErtu2Yxyo5KZHCkLQjWF1L1vOseI11RQZOyveHbnz0k3Y6-wpwKjmYCcIq_Jg1b8dZwe19XvFJG_ppsqAF_eA4H8uGJOabNQ4juDQL1FRUYmayzw9S5__J935Jbj8PEWbltWNoPIAfPa3owcrf74yC14eBd20e-jSSh3ioXI81CEe6hgP9huGzrG8</recordid><startdate>20140305</startdate><enddate>20140305</enddate><creator>Belen, Burcu</creator><creator>Hismi, Burcu Ozturk</creator><creator>Kocak, Ulker</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140305</creationdate><title>Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia</title><author>Belen, Burcu ; Hismi, Burcu Ozturk ; Kocak, Ulker</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3552-1cdcf7456c9ecf0bae71981e49a4c88b34a194fde1a5516f32d9844e0421c1e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>12 months</topic><topic>Anemia</topic><topic>Anemia, Myelophthisic - diagnosis</topic><topic>Anemia, Myelophthisic - etiology</topic><topic>Anemia, Pernicious - complications</topic><topic>Anemia, Pernicious - diagnosis</topic><topic>Bone marrow</topic><topic>Breastfeeding & lactation</topic><topic>Dehydrogenases</topic><topic>Diagnosis, Differential</topic><topic>Granulocytes</topic><topic>Hemoglobin</topic><topic>Hepatomegaly - diagnosis</topic><topic>Hepatomegaly - etiology</topic><topic>Homocysteine</topic><topic>Humans</topic><topic>Infant</topic><topic>Laboratories</topic><topic>Leukemia</topic><topic>Male</topic><topic>Middle East</topic><topic>Neutrophils</topic><topic>Pancytopenia - diagnosis</topic><topic>Pancytopenia - etiology</topic><topic>Patients</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</topic><topic>Refugee camps</topic><topic>Refugees</topic><topic>Socioeconomic factors</topic><topic>Splenomegaly - diagnosis</topic><topic>Splenomegaly - etiology</topic><topic>Syria</topic><topic>Thrombocytopenia</topic><topic>Turkey</topic><topic>Unusual Association of Diseases/Symptoms</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belen, Burcu</creatorcontrib><creatorcontrib>Hismi, Burcu Ozturk</creatorcontrib><creatorcontrib>Kocak, Ulker</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belen, Burcu</au><au>Hismi, Burcu Ozturk</au><au>Kocak, Ulker</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2014-03-05</date><risdate>2014</risdate><volume>2014</volume><eissn>1757-790X</eissn><abstract>Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>24599434</pmid><doi>10.1136/bcr-2014-203742</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 12 months Anemia Anemia, Myelophthisic - diagnosis Anemia, Myelophthisic - etiology Anemia, Pernicious - complications Anemia, Pernicious - diagnosis Bone marrow Breastfeeding & lactation Dehydrogenases Diagnosis, Differential Granulocytes Hemoglobin Hepatomegaly - diagnosis Hepatomegaly - etiology Homocysteine Humans Infant Laboratories Leukemia Male Middle East Neutrophils Pancytopenia - diagnosis Pancytopenia - etiology Patients Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Refugee camps Refugees Socioeconomic factors Splenomegaly - diagnosis Splenomegaly - etiology Syria Thrombocytopenia Turkey Unusual Association of Diseases/Symptoms Uric acid |
| title | Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia |
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