Severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis in two Syrian refugee infants: a challenge to differentiate from acute leukaemia

Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian re...

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Veröffentlicht in:	BMJ case reports 2014-03, Vol.2014
Hauptverfasser:	Belen, Burcu, Hismi, Burcu Ozturk, Kocak, Ulker
Format:	Artikel
Sprache:	eng
Schlagworte:	12 months Anemia Anemia, Myelophthisic - diagnosis Anemia, Myelophthisic - etiology Anemia, Pernicious - complications Anemia, Pernicious - diagnosis Bone marrow Breastfeeding & lactation Dehydrogenases Diagnosis, Differential Granulocytes Hemoglobin Hepatomegaly - diagnosis Hepatomegaly - etiology Homocysteine Humans Infant Laboratories Leukemia Male Middle East Neutrophils Pancytopenia - diagnosis Pancytopenia - etiology Patients Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Refugee camps Refugees Socioeconomic factors Splenomegaly - diagnosis Splenomegaly - etiology Syria Thrombocytopenia Turkey Unusual Association of Diseases/Symptoms Uric acid
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Zusammenfassung:	Megaloblastic anaemia due to vitamin B12 deficiency is rare in childhood. However, as most cases are due to maternal insufficiency, it is mainly seen in breastfed infants especially when the mother's socioeconomic status is low and the nutrition is not adequate. We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.
ISSN:	1757-790X
DOI:	10.1136/bcr-2014-203742