53BP1: pro choice in DNA repair

Highlights • 53BP1 regulates the choice between two major DSB repair pathways. • 53BP1 binds damaged chromatin through multiple histone modifications. • 53BP1 promotes classical nonhomologous end joining in various specialized contexts. • 53BP1 blocks 5′ end resection and facilitates mobility and sy...

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Veröffentlicht in:	Trends in cell biology 2014-02, Vol.24 (2), p.108-117
Hauptverfasser:	Zimmermann, Michal, de Lange, Titia
Format:	Artikel
Sprache:	eng
Schlagworte:	53BP1 BRCA1 CSR DNA Repair HDR Humans Intracellular Signaling Peptides and Proteins - metabolism NHEJ PARPi Pathology PTIP resection Rif1 telomere Tumor Suppressor p53-Binding Protein 1 V(D)J
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Beschreibung
Zusammenfassung:	Highlights • 53BP1 regulates the choice between two major DSB repair pathways. • 53BP1 binds damaged chromatin through multiple histone modifications. • 53BP1 promotes classical nonhomologous end joining in various specialized contexts. • 53BP1 blocks 5′ end resection and facilitates mobility and synapsis of chromatin. • 53BP1 recruits interacting partners Rif1 and PTIP to block resection.
ISSN:	0962-8924 1879-3088
DOI:	10.1016/j.tcb.2013.09.003