Long-Term Coffee Consumption and Risk of Cardiovascular Disease: A Systematic Review and a Dose–Response Meta-Analysis of Prospective Cohort Studies

BACKGROUND—Considerable controversy exists on the association between coffee consumption and cardiovascular disease (CVD) risk. A meta-analysis was performed to assess the dose–response relationship of long-term coffee consumption with CVD risk. METHODS AND RESULTS—PubMed and EMBASE were searched fo...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2014-02, Vol.129 (6), p.643-659
Hauptverfasser:	Ding, Ming, Bhupathiraju, Shilpa N, Satija, Ambika, van Dam, Rob M, Hu, Frank B
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - mortality Coffee - adverse effects Coronary Disease - mortality Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Failure - mortality Humans Medical sciences Nonlinear Dynamics Prospective Studies Risk Factors Stroke - mortality
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Zusammenfassung:	BACKGROUND—Considerable controversy exists on the association between coffee consumption and cardiovascular disease (CVD) risk. A meta-analysis was performed to assess the dose–response relationship of long-term coffee consumption with CVD risk. METHODS AND RESULTS—PubMed and EMBASE were searched for prospective cohort studies of the relationship between coffee consumption and CVD risk, which included coronary heart disease, stroke, heart failure, and CVD mortality. Thirty-six studies were included with 1 279 804 participants and 36 352 CVD cases. A nonlinear relationship of coffee consumption with CVD risk was identified (P for heterogeneity=0.09, P for trend
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.113.005925