Vitamin E is essential for Purkinje neuron integrity

Highlights • Vitamin E deficiency results in elevated oxidative stress in the cerebellum. • Vitamin E deficiency results in impaired motor and cognitive functions. • Vitamin E deficiency results in deterioration of Purkinje neurons. • Vitamin E supplementation prevents anatomic and functional damage...

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Veröffentlicht in:	Neuroscience 2014-02, Vol.260, p.120-129
Hauptverfasser:	Ulatowski, L, Parker, R, Warrier, G, Sultana, R, Butterfield, D.A, Manor, D
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Tocopherol - blood alpha-Tocopherol - pharmacology Animals ataxia Biological and medical sciences Carrier Proteins - genetics cerebellum Cerebellum - drug effects Cerebellum - metabolism Cerebellum - pathology Fundamental and applied biological sciences. Psychology Mice Mice, Knockout Motor Activity - drug effects Motor Activity - physiology Neurology oxidative stress Oxidative Stress - drug effects Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Purkinje Cells - drug effects Purkinje Cells - metabolism Purkinje Cells - pathology Purkinje neuron tocopherol Tyrosine - analogs & derivatives Tyrosine - metabolism Vertebrates: nervous system and sense organs vitamin E Vitamin E Deficiency - pathology Vitamin E Deficiency - physiopathology
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Beschreibung
Zusammenfassung:	Highlights • Vitamin E deficiency results in elevated oxidative stress in the cerebellum. • Vitamin E deficiency results in impaired motor and cognitive functions. • Vitamin E deficiency results in deterioration of Purkinje neurons. • Vitamin E supplementation prevents anatomic and functional damage. • Adequate vitamin E status is essential for optimal neurological health.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.12.001