Genetic polymorphisms in host antiviral genes: Associations with humoral and cellular immunity to measles vaccine

Highlights ► We assessed 307 SNPs in 12 antiviral genes, in a cohort of MMR-vaccinated subjects. ► DDX58 SNPs were associated with measles-specific antibody variations in Caucasians. ► ADAR SNPs were associated with measles-specific cellular immunity in Caucasians. ► DDX58 SNPs were associated with...

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Veröffentlicht in:	Vaccine 2011-11, Vol.29 (48), p.8988-8997
Hauptverfasser:	Haralambieva, Iana H, Ovsyannikova, Inna G, Umlauf, Benjamin J, Vierkant, Robert A, Shane Pankratz, V, Jacobson, Robert M, Poland, Gregory A
Format:	Artikel
Sprache:	eng
Schlagworte:	2',5'-Oligoadenylate Synthetase - genetics Adaptive Immunity Adenosine Deaminase - genetics Adolescent African Americans alleles Allergy and Immunology Antibodies, Neutralizing - blood Antibodies, Viral - blood Antiviral genes Applied microbiology Biological and medical sciences Black or African American cell-mediated immunity Child Children & youth DEAD Box Protein 58 DEAD-box RNA Helicases - genetics Female Fundamental and applied biological sciences. Psychology Genes Genotype Haplotypes Human viral diseases Humans immune response Immune system Immunity Immunity, Cellular Immunity, Humoral Infectious diseases interferon-gamma interleukin-2 Kinases Linear Models Male Measles - genetics Measles - immunology Measles vaccine Measles-Mumps-Rubella Vaccine - administration & dosage Measles-Mumps-Rubella Vaccine - immunology Medical sciences Microbiology Minnesota Neutralization Tests neutralizing antibodies Polymorphism, Single Nucleotide Receptors, Immunologic RNA-Binding Proteins school children secretion single nucleotide polymorphism Single nucleotide polymorphisms vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye White People Whites Young Adult
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Beschreibung
Zusammenfassung:	Highlights ► We assessed 307 SNPs in 12 antiviral genes, in a cohort of MMR-vaccinated subjects. ► DDX58 SNPs were associated with measles-specific antibody variations in Caucasians. ► ADAR SNPs were associated with measles-specific cellular immunity in Caucasians. ► DDX58 SNPs were associated with both IFNγ and IL-2 cytokine secretion in Caucasians. ► Two OAS1 SNPs demonstrated associations with humoral immunity in African-Americans.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.09.043