Replication proteins and human disease

In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerge...

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Veröffentlicht in:Cold Spring Harbor perspectives in biology 2014-01, Vol.6 (1), p.a013060-a013060
Hauptverfasser: Jackson, Andrew P, Laskey, Ronald A, Coleman, Nicholas
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Sprache:eng
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Zusammenfassung:In this article, we discuss the significance of DNA replication proteins in human disease. There is a broad range of mutations in genes encoding replication proteins, which result in several distinct clinical disorders that share common themes. One group of replication proteins, the MCMs, has emerged as effective biomarkers for early detection of a range of common cancers. They offer practical and theoretical advantages over other replication proteins and have been developed for widespread clinical use.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a013060