Exogenous interleukin-10 alleviates allergic inflammation but inhibits local interleukin-10 expression in a mouse allergic rhinitis model

Interleukin-10 (IL-10) has an important anti-inflammatory and immunoregulatory function, and its expression is negatively correlated with the development and severity of allergic rhinitis (AR). However, the in vivo effects of exogenous IL-10 on AR have not been studied and the mechanisms underlying...

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Veröffentlicht in:	BMC immunology 2014-02, Vol.15 (1), p.9-9, Article 9
Hauptverfasser:	Wang, Shui-Bin, Deng, Yu-Qin, Ren, Jie, Xiao, Bo-Kui, Liu, Zheng, Tao, Ze-Zhang
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Analysis Animals Cytokines Cytokines - genetics Cytokines - metabolism Dehydrogenases Disease Models, Animal Eosinophils - drug effects Eosinophils - immunology Gene Expression Regulation - drug effects Genetic aspects Immune system Interleukin-10 - genetics Interleukin-10 - metabolism Interleukin-10 - pharmacology Lymphocytes Mast Cells - drug effects Mast Cells - immunology Mice Nasal Mucosa - cytology Nasal Mucosa - drug effects Nasal Mucosa - immunology Otolaryngology Physiological aspects Proteins Recombinant Proteins - pharmacology Rhinitis, Allergic Rhinitis, Allergic, Perennial - genetics Rhinitis, Allergic, Perennial - immunology Rhinitis, Allergic, Perennial - metabolism Surgery T cells T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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