Molecular mechanisms underlying chronic inflammation-associated cancers
Highlights • Redox-related transcription factor upregulation characterizes inflammation-related cancer. • NADPH oxidase-dependent ROS are associated with inflammation and tumor promotion. • Interdicting ROS-mediated inflammation is a novel cancer prevention strategy.
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| Veröffentlicht in: | Cancer letters 2014-04, Vol.345 (2), p.164-173 |
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| container_end_page | 173 |
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| container_issue | 2 |
| container_start_page | 164 |
| container_title | Cancer letters |
| container_volume | 345 |
| creator | Wu, Yongzhong Antony, Smitha Meitzler, Jennifer L Doroshow, James H |
| description | Highlights • Redox-related transcription factor upregulation characterizes inflammation-related cancer. • NADPH oxidase-dependent ROS are associated with inflammation and tumor promotion. • Interdicting ROS-mediated inflammation is a novel cancer prevention strategy. |
| doi_str_mv | 10.1016/j.canlet.2013.08.014 |
| format | Article |
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therapeutic use</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>Cancer</subject><subject>Cell growth</subject><subject>Cell Transformation, Neoplastic - immunology</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Chronic Disease</subject><subject>Cytokines</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA damage</subject><subject>Enzymes</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Hypoxia</subject><subject>Immune system</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - complications</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation - genetics</subject><subject>Inflammation - immunology</subject><subject>Inflammation - metabolism</subject><subject>Inflammation Mediators - metabolism</subject><subject>Inflammatory bowel disease</subject><subject>Kinases</subject><subject>Liver cancer</subject><subject>NADPH oxidase</subject><subject>NADPH Oxidases - metabolism</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - etiology</subject><subject>Neoplasms - genetics</subject><subject>Neoplasms - immunology</subject><subject>Neoplasms - metabolism</subject><subject>Oxidative Stress</subject><subject>Pancreatic cancer</subject><subject>Phosphorylation</subject><subject>Prostate cancer</subject><subject>Proteins</subject><subject>Reactive oxygen</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Signal Transduction</subject><subject>Stress</subject><subject>Transcription factors</subject><subject>Transcription Factors - metabolism</subject><subject>Tumor Microenvironment</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxS0EokvhGyAUiXOC_8SxfUFCFW2RWnEAzpbjjLteHLvYSaX99ni1pQUuPfngmffe_GYQektwRzAZPuw6a2KApaOYsA7LDpP-GdoQKWgrlMTP0QYz3LdMMn6CXpWywxjzXvCX6IQyJSUdxAZdXKcAdg0mNzPYrYm-zKVZ4wQ57H28aew2p-ht46MLZp7N4lNsTSnJerPA1NQQFnJ5jV44Ewq8uX9P0Y_zz9_PLturrxdfzj5dtZb3w9IKoZQclcOEDKPgYuRgJi7tIJXjg-spd1w6OVHbWzzRQVGimJGO0UmNrh_ZKfp41L1dxxkmC3HJJujb7GeT9zoZr__9iX6rb9KdZorx6l0F3t8L5PRrhbLoXVpzrJk14ZUPF0SRWtUfq2xOpWRwDw4E6wN-vdNH_PqAX2OpK_7a9u7vdA9Nf3g_xofK6M5D1sV6qAQnn8Euekr-KYf_BWzwdT8m_IQ9lMdZdKEa62-HEzhcAGF1-VJR9ht4XK69</recordid><startdate>20140410</startdate><enddate>20140410</enddate><creator>Wu, Yongzhong</creator><creator>Antony, Smitha</creator><creator>Meitzler, Jennifer L</creator><creator>Doroshow, James H</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>5PM</scope></search><sort><creationdate>20140410</creationdate><title>Molecular mechanisms underlying chronic inflammation-associated cancers</title><author>Wu, Yongzhong ; Antony, Smitha ; Meitzler, Jennifer L ; Doroshow, James H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-77998b9f0116b757b5ead58c689f56f425f58f8d2c4c0d2692193a8f32d9bf4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Angiogenesis</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - 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| ispartof | Cancer letters, 2014-04, Vol.345 (2), p.164-173 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Angiogenesis Animals Anti-Inflammatory Agents - therapeutic use Antineoplastic Agents - therapeutic use Apoptosis Cancer Cell growth Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - metabolism Chronic Disease Cytokines Deoxyribonucleic acid DNA DNA damage Enzymes Hematology, Oncology and Palliative Medicine Hepatitis Humans Hypoxia Immune system Infections Inflammation Inflammation - complications Inflammation - drug therapy Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Inflammatory bowel disease Kinases Liver cancer NADPH oxidase NADPH Oxidases - metabolism Neoplasms - drug therapy Neoplasms - etiology Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Oxidative Stress Pancreatic cancer Phosphorylation Prostate cancer Proteins Reactive oxygen Reactive Oxygen Species - metabolism Signal Transduction Stress Transcription factors Transcription Factors - metabolism Tumor Microenvironment Tumors |
| title | Molecular mechanisms underlying chronic inflammation-associated cancers |
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