Molecular mechanisms underlying chronic inflammation-associated cancers

Highlights • Redox-related transcription factor upregulation characterizes inflammation-related cancer. • NADPH oxidase-dependent ROS are associated with inflammation and tumor promotion. • Interdicting ROS-mediated inflammation is a novel cancer prevention strategy.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2014-04, Vol.345 (2), p.164-173
Hauptverfasser:	Wu, Yongzhong, Antony, Smitha, Meitzler, Jennifer L, Doroshow, James H
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Anti-Inflammatory Agents - therapeutic use Antineoplastic Agents - therapeutic use Apoptosis Cancer Cell growth Cell Transformation, Neoplastic - immunology Cell Transformation, Neoplastic - metabolism Chronic Disease Cytokines Deoxyribonucleic acid DNA DNA damage Enzymes Hematology, Oncology and Palliative Medicine Hepatitis Humans Hypoxia Immune system Infections Inflammation Inflammation - complications Inflammation - drug therapy Inflammation - genetics Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Inflammatory bowel disease Kinases Liver cancer NADPH oxidase NADPH Oxidases - metabolism Neoplasms - drug therapy Neoplasms - etiology Neoplasms - genetics Neoplasms - immunology Neoplasms - metabolism Oxidative Stress Pancreatic cancer Phosphorylation Prostate cancer Proteins Reactive oxygen Reactive Oxygen Species - metabolism Signal Transduction Stress Transcription factors Transcription Factors - metabolism Tumor Microenvironment Tumors
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Beschreibung
Zusammenfassung:	Highlights • Redox-related transcription factor upregulation characterizes inflammation-related cancer. • NADPH oxidase-dependent ROS are associated with inflammation and tumor promotion. • Interdicting ROS-mediated inflammation is a novel cancer prevention strategy.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.08.014