Cross-species protection: Schistosoma mansoni Sm-p80 vaccine confers protection against Schistosoma haematobium in hamsters and baboons

Highlights • Sm-p80 vaccine originally developed for Schistosoma mansoni confers protection against Schistosoma haematobium. • Sm-p80 vaccine has a high likelihood of success against both intestinal and urinary schistosomiasis. • Schistosomiasis control should encompass mass drug/vaccine administrat...

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Veröffentlicht in:	Vaccine 2014-03, Vol.32 (11), p.1296-1303
Hauptverfasser:	Karmakar, Souvik, Zhang, Weidong, Ahmad, Gul, Torben, Workineh, Alam, Mayeen U, Le, Loc, Damian, Raymond T, Wolf, Roman F, White, Gary L, Carey, David W, Carter, Darrick, Reed, Steven G, Siddiqui, Afzal A
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Helminth - blood Antibody Formation Antigens, Helminth - immunology Applied microbiology Baboons Biological and medical sciences Biomedical research Bladder Calpain Cricetinae Cross Protection Cytokines - immunology Disease Models, Animal Diseases caused by trematodes Eggs Feces Female Fundamental and applied biological sciences. Psychology Helminthic diseases Host parasite relation pathogenicity Immunity, Cellular Infections Infectious diseases Intestinal schistosomiasis Invertebrates Male Medical sciences Microbiology Nemathelminthia. Plathelmintha Nonhuman primate Papio Parasite Egg Count Parasites Parasitic diseases Pilot Projects Protected species Proteins Rodents Schistosoma haematobium Schistosoma haematobium - pathogenicity Schistosoma mansoni Schistosoma mansoni - immunology Schistosome vaccine Schistosomiases Schistosomiasis Schistosomiasis - prevention & control Sm-p80 Tropical diseases Urinary bladder Urinary schistosomiasis Vaccines Vaccines - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Synthetic - immunology
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Beschreibung
Zusammenfassung:	Highlights • Sm-p80 vaccine originally developed for Schistosoma mansoni confers protection against Schistosoma haematobium. • Sm-p80 vaccine has a high likelihood of success against both intestinal and urinary schistosomiasis. • Schistosomiasis control should encompass mass drug/vaccine administration or MDVA: a vaccine implementation scheme that would entail treating infected individuals with praziquantel and then vaccinating them with a schistosome vaccine.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.12.057