Composite Three-Dimensional Woven Scaffolds with Interpenetrating Network Hydrogels to Create Functional Synthetic Articular Cartilage
The development of synthetic biomaterials that possess mechanical properties mimicking those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelastic, and anisotropic material that exhibits a very low coeffici...
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Veröffentlicht in: | Advanced functional materials 2013-12, Vol.23 (47), p.5833-5839 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The development of synthetic biomaterials that possess mechanical properties mimicking those of native tissues remains an important challenge to the field of materials. In particular, articular cartilage is a complex nonlinear, viscoelastic, and anisotropic material that exhibits a very low coefficient of friction, allowing it to withstand millions of cycles of joint loading over decades of wear. Here, a three‐dimensionally woven fiber scaffold that is infiltrated with an interpenetrating network hydrogel can build a functional biomaterial that provides the load‐bearing and tribological properties of native cartilage. An interpenetrating dual‐network “tough‐gel” consisting of alginate and polyacrylamide was infused into a porous three‐dimensionally woven poly(ϵ‐caprolactone) fiber scaffold, providing a versatile fiber‐reinforced composite structure as a potential acellular or cell‐based replacement for cartilage repair.
A three‐dimensionally woven fiber scaffold (left) shows significant reduction in surface roughness after being infused with an interpenetrating network (IPN) hydrogel consisting of alginate and polyacrylamide (right), as measured using an optical profiler. These fiber‐reinforced IPN scaffolds provide a versatile composite structure as a potential acellular or cell‐based replacement for tissue repair. |
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ISSN: | 1616-301X 1616-3028 |
DOI: | 10.1002/adfm.201300483 |