Tumor antigenicity revealed

Tumor antigenicity revealed

The extent to which mutated peptide antigens encoded by somatic mutations contribute to tumor antigenicity in human cancer patients has been unclear. Two recent studies using tumor exome sequencing to predict candidate mutated antigens provide insight into this question.

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Bibliographische Detailangaben
Veröffentlicht in:Trends in immunology 2014-02, Vol.35 (2), p.47-48
1. Verfasser: Savage, Peter A
Format: Artikel
Sprache:eng
Schlagworte:
Allergy and Immunology
Animals
Antigens
Humans
Immunotherapy
Immunotherapy, Adoptive - methods
Mutation
Neoplasms - immunology
Neoplasms - therapy
T cell receptors
T-Lymphocytes - immunology
T-Lymphocytes - transplantation
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Beschreibung
Zusammenfassung:The extent to which mutated peptide antigens encoded by somatic mutations contribute to tumor antigenicity in human cancer patients has been unclear. Two recent studies using tumor exome sequencing to predict candidate mutated antigens provide insight into this question.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2014.01.001