Decreased Thioredoxin-1 and Increased HSP90 Expression in Skeletal Muscle in Subjects with Type 2 Diabetes or Impaired Glucose Tolerance

In diabetes, the endogenous defence systems are overwhelmed, causing various types of stress in tissues. In this study, newly diagnosed or diet-treated type 2 diabetics (T2D) (n=10) were compared with subjects with impaired glucose tolerance (IGT) (n=8). In both groups, at resting conditions, blood...

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Veröffentlicht in:	BioMed research international 2014-01, Vol.2014 (2014), p.1-6
Hauptverfasser:	Venojärvi, M., Korkmaz, A., Aunola, S., Hällsten, K., Virtanen, K., Marniemi, J., Halonen, J.-P., Hänninen, O., Nuutila, P., Atalay, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomedical research Blood Glucose - metabolism Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Female Glucose Glucose intolerance Glucose Intolerance - metabolism Glucose Intolerance - pathology Health aspects Heat shock proteins HSP72 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - metabolism Humans Insulin Kinases Male Middle Aged Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscles Muscular system Physiological aspects Rodents Thioredoxin Thioredoxins - metabolism Type 2 diabetes
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Zusammenfassung:	In diabetes, the endogenous defence systems are overwhelmed, causing various types of stress in tissues. In this study, newly diagnosed or diet-treated type 2 diabetics (T2D) (n=10) were compared with subjects with impaired glucose tolerance (IGT) (n=8). In both groups, at resting conditions, blood samples were drawn for assessing metabolic indices and skeletal muscle samples (m. vastus lateralis) were taken for the measurements of cellular defence markers: thioredoxin-1 (TRX-1) and stress proteins HSP72, HSP90. The protein level of TRX-1 was 36.1% lower (P=0.031) and HSP90 was 380% higher (P
ISSN:	2314-6133 2314-6141
DOI:	10.1155/2014/386351