Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell (Scrophulariaceae)

Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. Endophytic fungi were isolated from the Bacop...

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Veröffentlicht in:	BMC complementary and alternative medicine 2014-02, Vol.14 (1), p.52-52, Article 52
Hauptverfasser:	Katoch, Meenu, Singh, Gurpreet, Sharma, Sadhna, Gupta, Nidhi, Sangwan, Payare Lal, Saxena, Ajit Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - pharmacology Anti-Infective Agents - therapeutic use Antimicrobial agents antimicrobial properties Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bacopa - microbiology Bacopa monnieri Biological Products - pharmacology Biological Products - therapeutic use Cancer cell lines Colorectal Neoplasms - drug therapy complement Cytotoxicity endophytes Endophytes - isolation & purification Fungi Fungi - isolation & purification HCT116 Cells Humans industry Inhibitory Concentration 50 Integrative medicine Leaves Light liquids MCF-7 Cells Medicine Metabolites Microscopy Morphology neoplasm cells Neoplasms - drug therapy Phylogenetics Scrophulariaceae toxicity testing
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Zusammenfassung:	Endophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated. Endophytic fungi were isolated from the Bacopa monnieri. Extracts from liquid cultures were tested for cytotoxicity against a number of cancer cell lines using the MTT assay. Antimicrobial activity was determined using the micro dilution method. 22% of the examined extracts showed potent (IC50 of
ISSN:	1472-6882 1472-6882
DOI:	10.1186/1472-6882-14-52