ImmunoPods: Polymer Shells with Native Antibody Cross-Links

ImmunoPods: Polymer Shells with Native Antibody Cross-Links

Nanopods functionalized with anti‐HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross‐linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow...

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Veröffentlicht in:Angewandte Chemie International Edition 2012-01, Vol.51 (5), p.1169-1172
Hauptverfasser: Zhang, Ke, Zheng, Dan, Hao, Liangliang, Cutler, Joshua I., Auyeung, Evelyn, Mirkin, Chad A.
Format: Artikel
Sprache:eng
Schlagworte:
antibodies
Antibodies - chemistry
Cross-Linking Reagents - chemistry
gold
HER2
Humans
Immunoconjugates - chemistry
Microscopy, Confocal
nanoparticles
Polymers
Polymers - chemistry
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Zusammenfassung:Nanopods functionalized with anti‐HER2 antibodies (ImmunoPods, see scheme) have been synthesized by adsorbing the proteins onto gold nanoparticles and catalytically cross‐linking them with a coadsorbed polymer through pendant propargyl ether groups. Upon dissolution of the gold template, the hollow polymer nanopod–protein conjugates remain. ImmunoPods are bioactive and can target cancer cells that express the HER2 antigen.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201106313