Cell targeting by the Staphylococcus aureus pore-forming toxins: it's not just about lipids

Highlights • Staphylococcus aureus pore-forming toxins (PFTs) use different proteinaceous receptors to target host cells. • Receptors explain cell-type and species tropisms exhibited by S. aureus toxins. • Human-specific receptors underscore the limitations of animal models in PFT research.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in microbiology (Regular ed.) 2014-01, Vol.22 (1), p.21-27
Hauptverfasser:	DuMont, Ashley L, Torres, Victor J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Toxins - metabolism Disease Models, Animal Humans Internal Medicine membrane proteins pore-forming toxins Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus Staphylococcus aureus - metabolism Staphylococcus aureus - pathogenicity toxin receptors Virulence Virulence Factors - metabolism
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Beschreibung
Zusammenfassung:	Highlights • Staphylococcus aureus pore-forming toxins (PFTs) use different proteinaceous receptors to target host cells. • Receptors explain cell-type and species tropisms exhibited by S. aureus toxins. • Human-specific receptors underscore the limitations of animal models in PFT research.
ISSN:	0966-842X 1878-4380
DOI:	10.1016/j.tim.2013.10.004