Treg cells: a potential regulator for IL-22 expression?

Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23 and several transcription factors, including STAT3, RORγt, and the AhR are important stimulus. Recently, there is em...

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Veröffentlicht in:	International journal of clinical and experimental pathology 2014-01, Vol.7 (2), p.474-480
Hauptverfasser:	Lin, Shuman, Yang, Xuyan, Liang, Dian, Zheng, Song Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Communication Gene Expression Regulation Humans Immunity, Innate Interleukin-22 Interleukins - genetics Interleukins - metabolism Review Signal Transduction T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism
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Beschreibung
Zusammenfassung:	Inteleurkin-22 (IL-22) is a IL-10 family cytokine member and is mainly produced by innate lymphoid cells (ILCs), Th17 cells, and Th22 cells. Previous studies have indicated that IL-23 and several transcription factors, including STAT3, RORγt, and the AhR are important stimulus. Recently, there is emerging evidence that Tregs can regulate IL-22 expression. In the review, we discuss the updated advancement on Tregs function and its regulatory role on IL-22 expression.
ISSN:	1936-2625