PEG1/MEST and IGF2 DNA methylation in CIN and in cervical cancer

Introduction Although most invasive cervical cancer (ICC) harbor 30 years further strengthened these associations. Conclusions While the small sample size limits inference, these findings show that altered DNA methylation at imprinted domains including IGF2/H19 and PEG1/MEST may mediate the associat...

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Veröffentlicht in:	Clinical & translational oncology 2014-03, Vol.16 (3), p.266-272
Hauptverfasser:	Vidal, A. C., Henry, N. M., Murphy, S. K., Oneko, O., Nye, M., Bartlett, J. A., Overcash, F., Huang, Z., Wang, F., Mlay, P., Obure, J., Smith, J., Vasquez, B., Swai, B., Hernandez, B., Hoyo, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cervical Intraepithelial Neoplasia - genetics Cervical Intraepithelial Neoplasia - virology DNA Methylation Female Humans Insulin-Like Growth Factor II - genetics Medicine Medicine & Public Health Middle Aged Oncology Papillomavirus Infections - complications Papillomavirus Infections - genetics Proteins - genetics Research Article Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - virology
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Zusammenfassung:	Introduction Although most invasive cervical cancer (ICC) harbor 30 years further strengthened these associations. Conclusions While the small sample size limits inference, these findings show that altered DNA methylation at imprinted domains including IGF2/H19 and PEG1/MEST may mediate the association between HPV and ICC risk.
ISSN:	1699-048X 1699-3055
DOI:	10.1007/s12094-013-1067-4