Citalopram enhances neurovascular regeneration and sensorimotor functional recovery after ischemic stroke in mice

Highlights • Citalopram treatment enhances neural progenitor migration. • Citalopram treatment enhances neurogenesis in the peri-infarct cortex. • Citalopram treatment increases vessel peri-infarct representation. • Citalopram treatment increases BDNF expression in the peri-infarct region. • Citalop...

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Veröffentlicht in:	Neuroscience 2013-09, Vol.247, p.1-11
Hauptverfasser:	Espinera, A.R, Ogle, M.E, Gu, X, Wei, L
Format:	Artikel
Sprache:	eng
Schlagworte:	angiogenesis Animals Biological and medical sciences Brain Ischemia - drug therapy Brain Ischemia - pathology Brain Ischemia - physiopathology citalopram Citalopram - pharmacology Citalopram - therapeutic use Fundamental and applied biological sciences. Psychology ischemic stroke Male Medical sciences Mice Mice, Inbred C57BL Nerve Regeneration - drug effects Nerve Regeneration - physiology neurogenesis Neurogenesis - drug effects Neurogenesis - physiology Neurology Random Allocation Recovery of Function - drug effects Recovery of Function - physiology SSRI Stroke - drug therapy Stroke - pathology Stroke - physiopathology Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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Zusammenfassung:	Highlights • Citalopram treatment enhances neural progenitor migration. • Citalopram treatment enhances neurogenesis in the peri-infarct cortex. • Citalopram treatment increases vessel peri-infarct representation. • Citalopram treatment increases BDNF expression in the peri-infarct region. • Citalopram treatment after stroke promotes sensorimotor recovery.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.04.011