Regenerative medicine： Transdifferentiation in vivo

A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and co...

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Veröffentlicht in:	Cell research 2014-02, Vol.24 (2), p.141-142
Hauptverfasser:	Fu, Lina, Zhu, Xiping, Yi, Fei, Liu, Guang-Hui, Belmonte, Juan Carlos Izpisua
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136/532/2128 631/61/490 Animals Biomedical and Life Sciences Cell Biology Cell Transdifferentiation Cellular Reprogramming Genetic Vectors - genetics Genetic Vectors - metabolism Life Sciences Mice Physiology Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Pluripotent Stem Cells - transplantation Regenerative Medicine Research Highlight Transcription Factors - genetics Transcription Factors - metabolism 体内体外培养再生医学医学应用基细胞细胞移植转分化靶细胞
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Zusammenfassung:	A major challenge in regenerative medicine is the generation of functionally effective target cells to replace or repair damaged tissues. Transdifferentiation in vivo is a novel strategy to achieve cell fate conversion within the native physiological niche; this technology may provide a time- and cost-effective alternative for applications in regenerative medicine and may also minimize the concerns associated with in vitro culture and cell transplantation.
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2013.165