Cortical Folding Is Altered before Surgery in Infants with Congenital Heart Disease

Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right...

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Veröffentlicht in:	The Journal of pediatrics 2013-11, Vol.163 (5), p.1507-1510
Hauptverfasser:	Ortinau, Cynthia, MD, Alexopoulos, Dimitrios, MS, Dierker, Donna, MS, Van Essen, David, PhD, Beca, John, MBChB, Inder, Terrie, MBChB, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	brain Brain Mapping Cerebral Cortex - abnormalities Female Frontal Lobe - abnormalities Gyrus Cinguli - abnormalities Heart Defects, Congenital - physiopathology Heart Defects, Congenital - surgery heart diseases Humans Image Processing, Computer-Assisted Infant, Newborn infants Magnetic Resonance Imaging Male Pediatrics surface area surgery Term Birth
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Zusammenfassung:	Infants with congenital heart disease have altered brain development. We characterized cortical folding, a critical part of brain development, in congenital heart disease infants and demonstrated an overall decrease in cortical surface area and cortical folding with regional alterations in the right lateral sulcus and left orbitofrontal region, cingulate region, and central sulcus. These abnormalities were present prior to surgery.
ISSN:	0022-3476 1097-6833
DOI:	10.1016/j.jpeds.2013.06.045