Age at diagnosis and the utility of prognostic testing in patients with chronic lymphocytic leukemia

BACKGROUND: A study was undertaken to analyze the survival of chronic lymphocytic leukemia (CLL) patients relative to age‐matched individuals in the general population and determine the age‐stratified utility of prognostic testing. METHODS: All 2487 patients diagnosed with CLL between January 1995 a...

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Veröffentlicht in:	Cancer 2010-10, Vol.116 (20), p.4777-4787
Hauptverfasser:	Shanafelt, Tait D., Rabe, Kari G., Kay, Neil E., Zent, Clive S., Jelinek, Diane F., Reinalda, Megan S., Schwager, Susan M., Bowen, Debbie A., Slager, Susan L., Hanson, Curtis A., Call, Timothy G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age of Onset Aged Biological and medical sciences CD38 antigen chronic lymphocytic leukemia diagnosis Female Hematologic and hematopoietic diseases Humans Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - therapy Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Prognosis survival Survival Analysis Treatment Outcome Tumors
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Zusammenfassung:	BACKGROUND: A study was undertaken to analyze the survival of chronic lymphocytic leukemia (CLL) patients relative to age‐matched individuals in the general population and determine the age‐stratified utility of prognostic testing. METHODS: All 2487 patients diagnosed with CLL between January 1995 and June 2008 and cared for in the Mayo Clinic Division of Hematology were categorized by age at diagnosis and evaluated for differences in clinical characteristics, time to first treatment, and overall survival (OS). RESULTS: Among Rai stage 0 patients, survival was shorter than the age‐matched general population for patients aged
ISSN:	0008-543X 1097-0142 1097-0142
DOI:	10.1002/cncr.25292