Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies
Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a ne...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2014-01, Vol.32 (3), p.375-382 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 382 |
|---|---|
| container_issue | 3 |
| container_start_page | 375 |
| container_title | Vaccine |
| container_volume | 32 |
| creator | Robinette, Rebekah A Heim, Kyle P Oli, Monika W Crowley, Paula J McArthur, William P Brady, L. Jeannine |
| description | Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a new target of adherence-inhibiting antibodies. • An intramolecular interaction appears to dampen the adherence inhibiting immune response. |
| doi_str_mv | 10.1016/j.vaccine.2013.11.023 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3901311</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X13015405</els_id><sourcerecordid>1846311945</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5333-69fd9efb18e675ee6138c8b416e85fd7f1b3112565f8e60668a4f896dd00e2893</originalsourceid><addsrcrecordid>eNqFkk2P0zAQhiMEYrsLPwGUCxKXdj127DgcFlUrFipV4rAgcbNcZ7y4JHaxk0r99zhqWT4uPfngZ17PeJ6ieAVkAQTE9Xax18Y4jwtKgC0AFoSyJ8UMZM3mlIN8WswIFdW8AvLtorhMaUsI4Qya58UFrSinNeGzIiy7AaMeXPCpdL50fT_60Ibeee0NlsGW90PE3RBMMGZMZT8OOqPLh9X1avWuXGNKU2mHOnpsSxtDfwrpQzt2egjxUGo_uE1oHaYXxTOru4QvT-dV8fXuw5fbT_P154-r2-V6bjhjbC4a2zZoNyBR1BxRAJNGbioQKLltawsbBkC54DYTRAipKysb0baEIJUNuypujrm7cdNja9APUXdqF12v40EF7dS_N959Vw9hr1iTvxMgB7w9BcTwc8Q0qN4lg12nPYYxKZCVyFxT8fMoB1FXNWnoebRqSE0kh2kCfkRNDClFtI_NA1GTAmqrTgqoSQEFoLICue7135M_Vv3eeQbenACdjO5szIt26Q8nqWi4nHp9f-Qw72nvMKpkHGYpWhfRDKoN7mwrN_8lmM55lx_9gQdM2zBGnyVQoBJVRN1Pvk66AiPAq9zqL6C-6HU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1490708519</pqid></control><display><type>article</type><title>Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Robinette, Rebekah A ; Heim, Kyle P ; Oli, Monika W ; Crowley, Paula J ; McArthur, William P ; Brady, L. Jeannine</creator><creatorcontrib>Robinette, Rebekah A ; Heim, Kyle P ; Oli, Monika W ; Crowley, Paula J ; McArthur, William P ; Brady, L. Jeannine</creatorcontrib><description>Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a new target of adherence-inhibiting antibodies. • An intramolecular interaction appears to dampen the adherence inhibiting immune response.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2013.11.023</identifier><identifier>PMID: 24252705</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Allergy and Immunology ; Animals ; Antibodies, Bacterial - immunology ; antibody specificity ; Antigens, Bacterial - administration & dosage ; Antigens, Bacterial - genetics ; Antigens, Bacterial - immunology ; Applied microbiology ; Bacteriology ; Biological and medical sciences ; dental caries ; epitopes ; Epitopes, T-Lymphocyte - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; humans ; Immune complex ; Immunodominance ; Immunodominant Epitopes - administration & dosage ; Immunodominant Epitopes - genetics ; Immunodominant Epitopes - immunology ; Mice ; Mice, Inbred BALB C ; Microbiology ; Miscellaneous ; monoclonal antibodies ; Monoclonal antibody ; polypeptides ; protein structure ; Protein Structure, Tertiary ; Streptococcal Vaccines - administration & dosage ; Streptococcal Vaccines - genetics ; Streptococcal Vaccines - immunology ; Streptococcus ; Streptococcus mutans ; Streptococcus mutans - immunology ; T-lymphocytes ; Vaccine design ; vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2014-01, Vol.32 (3), p.375-382</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><rights>2013 Elsevier Ltd. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5333-69fd9efb18e675ee6138c8b416e85fd7f1b3112565f8e60668a4f896dd00e2893</citedby><cites>FETCH-LOGICAL-c5333-69fd9efb18e675ee6138c8b416e85fd7f1b3112565f8e60668a4f896dd00e2893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0264410X13015405$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28269582$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24252705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Robinette, Rebekah A</creatorcontrib><creatorcontrib>Heim, Kyle P</creatorcontrib><creatorcontrib>Oli, Monika W</creatorcontrib><creatorcontrib>Crowley, Paula J</creatorcontrib><creatorcontrib>McArthur, William P</creatorcontrib><creatorcontrib>Brady, L. Jeannine</creatorcontrib><title>Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a new target of adherence-inhibiting antibodies. • An intramolecular interaction appears to dampen the adherence inhibiting immune response.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Antibodies, Bacterial - immunology</subject><subject>antibody specificity</subject><subject>Antigens, Bacterial - administration & dosage</subject><subject>Antigens, Bacterial - genetics</subject><subject>Antigens, Bacterial - immunology</subject><subject>Applied microbiology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>dental caries</subject><subject>epitopes</subject><subject>Epitopes, T-Lymphocyte - immunology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>humans</subject><subject>Immune complex</subject><subject>Immunodominance</subject><subject>Immunodominant Epitopes - administration & dosage</subject><subject>Immunodominant Epitopes - genetics</subject><subject>Immunodominant Epitopes - immunology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>monoclonal antibodies</subject><subject>Monoclonal antibody</subject><subject>polypeptides</subject><subject>protein structure</subject><subject>Protein Structure, Tertiary</subject><subject>Streptococcal Vaccines - administration & dosage</subject><subject>Streptococcal Vaccines - genetics</subject><subject>Streptococcal Vaccines - immunology</subject><subject>Streptococcus</subject><subject>Streptococcus mutans</subject><subject>Streptococcus mutans - immunology</subject><subject>T-lymphocytes</subject><subject>Vaccine design</subject><subject>vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhiMEYrsLPwGUCxKXdj127DgcFlUrFipV4rAgcbNcZ7y4JHaxk0r99zhqWT4uPfngZ17PeJ6ieAVkAQTE9Xax18Y4jwtKgC0AFoSyJ8UMZM3mlIN8WswIFdW8AvLtorhMaUsI4Qya58UFrSinNeGzIiy7AaMeXPCpdL50fT_60Ibeee0NlsGW90PE3RBMMGZMZT8OOqPLh9X1avWuXGNKU2mHOnpsSxtDfwrpQzt2egjxUGo_uE1oHaYXxTOru4QvT-dV8fXuw5fbT_P154-r2-V6bjhjbC4a2zZoNyBR1BxRAJNGbioQKLltawsbBkC54DYTRAipKysb0baEIJUNuypujrm7cdNja9APUXdqF12v40EF7dS_N959Vw9hr1iTvxMgB7w9BcTwc8Q0qN4lg12nPYYxKZCVyFxT8fMoB1FXNWnoebRqSE0kh2kCfkRNDClFtI_NA1GTAmqrTgqoSQEFoLICue7135M_Vv3eeQbenACdjO5szIt26Q8nqWi4nHp9f-Qw72nvMKpkHGYpWhfRDKoN7mwrN_8lmM55lx_9gQdM2zBGnyVQoBJVRN1Pvk66AiPAq9zqL6C-6HU</recordid><startdate>20140109</startdate><enddate>20140109</enddate><creator>Robinette, Rebekah A</creator><creator>Heim, Kyle P</creator><creator>Oli, Monika W</creator><creator>Crowley, Paula J</creator><creator>McArthur, William P</creator><creator>Brady, L. Jeannine</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20140109</creationdate><title>Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies</title><author>Robinette, Rebekah A ; Heim, Kyle P ; Oli, Monika W ; Crowley, Paula J ; McArthur, William P ; Brady, L. Jeannine</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5333-69fd9efb18e675ee6138c8b416e85fd7f1b3112565f8e60668a4f896dd00e2893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Antibodies, Bacterial - immunology</topic><topic>antibody specificity</topic><topic>Antigens, Bacterial - administration & dosage</topic><topic>Antigens, Bacterial - genetics</topic><topic>Antigens, Bacterial - immunology</topic><topic>Applied microbiology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>dental caries</topic><topic>epitopes</topic><topic>Epitopes, T-Lymphocyte - immunology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>humans</topic><topic>Immune complex</topic><topic>Immunodominance</topic><topic>Immunodominant Epitopes - administration & dosage</topic><topic>Immunodominant Epitopes - genetics</topic><topic>Immunodominant Epitopes - immunology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>monoclonal antibodies</topic><topic>Monoclonal antibody</topic><topic>polypeptides</topic><topic>protein structure</topic><topic>Protein Structure, Tertiary</topic><topic>Streptococcal Vaccines - administration & dosage</topic><topic>Streptococcal Vaccines - genetics</topic><topic>Streptococcal Vaccines - immunology</topic><topic>Streptococcus</topic><topic>Streptococcus mutans</topic><topic>Streptococcus mutans - immunology</topic><topic>T-lymphocytes</topic><topic>Vaccine design</topic><topic>vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Robinette, Rebekah A</creatorcontrib><creatorcontrib>Heim, Kyle P</creatorcontrib><creatorcontrib>Oli, Monika W</creatorcontrib><creatorcontrib>Crowley, Paula J</creatorcontrib><creatorcontrib>McArthur, William P</creatorcontrib><creatorcontrib>Brady, L. Jeannine</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Robinette, Rebekah A</au><au>Heim, Kyle P</au><au>Oli, Monika W</au><au>Crowley, Paula J</au><au>McArthur, William P</au><au>Brady, L. Jeannine</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2014-01-09</date><risdate>2014</risdate><volume>32</volume><issue>3</issue><spage>375</spage><epage>382</epage><pages>375-382</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a new target of adherence-inhibiting antibodies. • An intramolecular interaction appears to dampen the adherence inhibiting immune response.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>24252705</pmid><doi>10.1016/j.vaccine.2013.11.023</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2014-01, Vol.32 (3), p.375-382 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3901311 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Animals Antibodies, Bacterial - immunology antibody specificity Antigens, Bacterial - administration & dosage Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacteriology Biological and medical sciences dental caries epitopes Epitopes, T-Lymphocyte - immunology Female Fundamental and applied biological sciences. Psychology humans Immune complex Immunodominance Immunodominant Epitopes - administration & dosage Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Mice Mice, Inbred BALB C Microbiology Miscellaneous monoclonal antibodies Monoclonal antibody polypeptides protein structure Protein Structure, Tertiary Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus Streptococcus mutans Streptococcus mutans - immunology T-lymphocytes Vaccine design vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T16%3A18%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Alterations%20in%20immunodominance%20of%20Streptococcus%20mutans%20AgI/II:%20Lessons%20learned%20from%20immunomodulatory%20antibodies&rft.jtitle=Vaccine&rft.au=Robinette,%20Rebekah%20A&rft.date=2014-01-09&rft.volume=32&rft.issue=3&rft.spage=375&rft.epage=382&rft.pages=375-382&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/j.vaccine.2013.11.023&rft_dat=%3Cproquest_pubme%3E1846311945%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1490708519&rft_id=info:pmid/24252705&rft_els_id=S0264410X13015405&rfr_iscdi=true |