Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies

Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a ne...

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Veröffentlicht in:	Vaccine 2014-01, Vol.32 (3), p.375-382
Hauptverfasser:	Robinette, Rebekah A, Heim, Kyle P, Oli, Monika W, Crowley, Paula J, McArthur, William P, Brady, L. Jeannine
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antibodies, Bacterial - immunology antibody specificity Antigens, Bacterial - administration & dosage Antigens, Bacterial - genetics Antigens, Bacterial - immunology Applied microbiology Bacteriology Biological and medical sciences dental caries epitopes Epitopes, T-Lymphocyte - immunology Female Fundamental and applied biological sciences. Psychology humans Immune complex Immunodominance Immunodominant Epitopes - administration & dosage Immunodominant Epitopes - genetics Immunodominant Epitopes - immunology Mice Mice, Inbred BALB C Microbiology Miscellaneous monoclonal antibodies Monoclonal antibody polypeptides protein structure Protein Structure, Tertiary Streptococcal Vaccines - administration & dosage Streptococcal Vaccines - genetics Streptococcal Vaccines - immunology Streptococcus Streptococcus mutans Streptococcus mutans - immunology T-lymphocytes Vaccine design vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Zusammenfassung:	Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a new target of adherence-inhibiting antibodies. • An intramolecular interaction appears to dampen the adherence inhibiting immune response.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.11.023