Activation of membrane estrogen receptors attenuates opioid receptor-like1 receptor-mediated antinociception via an ERK-dependent non-genomic mechanism

Highlights • Activation of mERs attenuates ORL1-analgesia via a rapid non-genomic mechanism. • Selective activation of GPR30, Gq-coupled mER, ERα attenuate ORL1-analgesia. • Activation of mERs attenuate ORL1-analgesia via an ERK-dependent mechanism in females.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-12, Vol.255, p.177-190
Hauptverfasser:	Small, K.M, Nag, S, Mokha, S.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Cell Membrane - metabolism estrogen receptor Extracellular Signal-Regulated MAP Kinases - metabolism Female Fundamental and applied biological sciences. Psychology GPR30 Male Neurology opiod receptor-like 1 (ORL1) receptor Ovariectomy pain Pain - metabolism Rats Rats, Sprague-Dawley Receptors, Estrogen - metabolism Receptors, Opioid - metabolism sex differences spinal cord Vertebrates: nervous system and sense organs
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Beschreibung
Zusammenfassung:	Highlights • Activation of mERs attenuates ORL1-analgesia via a rapid non-genomic mechanism. • Selective activation of GPR30, Gq-coupled mER, ERα attenuate ORL1-analgesia. • Activation of mERs attenuate ORL1-analgesia via an ERK-dependent mechanism in females.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.10.034