FTO Genotype, Vitamin D Status, and Weight Gain During Childhood
Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in...
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2014-02, Vol.63 (2), p.808-814 |
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| creator | LOURENCO, Barbara H LU QI WILLETT, Walter C CARDOSO, Marly A |
| description | Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged |
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We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged <10 years had complete genotypic and anthropometric data; 796 were followed up over a median 4.6 years. Baseline vitamin D insufficiency was defined as <75 nmol/L. We observed a 0.07 kg/m(2)/year increase in BMI and a 0.03 Z/year increase in BMI-for-age Z score per rs9939609 risk allele over follow-up (P = 0.01). Vitamin D status significantly modified FTO effects (P for interaction = 0.02). The rs9939609 risk allele was associated with a 0.05 Z/year increase in BMI-for-age Z score among vitamin D-insufficient children (P = 0.003), while no significant genetic effects were observed among vitamin D-sufficient children. Our data suggest that FTO rs9939609 affects child weight gain, and genotype effects are more pronounced among children with insufficient vitamin D levels.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db13-1290</identifier><identifier>PMID: 24130335</identifier><identifier>CODEN: DIAEAZ</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Alfacalcidol ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Biological and medical sciences ; Body mass index ; Calcifediol ; Child ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gene Expression Regulation, Developmental - physiology ; Genes ; Genetic aspects ; Genetic research ; Genetic susceptibility ; Genetics/Genomes/Proteomics/Metabolomics ; Genotype ; Genotype & phenotype ; Health aspects ; Humans ; Male ; Medical sciences ; Obesity ; Proteins - genetics ; Proteins - metabolism ; Vitamin D ; Vitamin D - metabolism ; Weight</subject><ispartof>Diabetes (New York, N.Y.), 2014-02, Vol.63 (2), p.808-814</ispartof><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2014 American Diabetes Association</rights><rights>COPYRIGHT 2014 American Diabetes Association</rights><rights>Copyright American Diabetes Association Feb 2014</rights><rights>2014 by the American Diabetes Association. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c610t-ae6dafb2268fad2a3ee0d77c028f729bc92ca60a9e6a2c8f67f9b2369fb67233</citedby><cites>FETCH-LOGICAL-c610t-ae6dafb2268fad2a3ee0d77c028f729bc92ca60a9e6a2c8f67f9b2369fb67233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900536/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900536/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28203616$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24130335$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOURENCO, Barbara H</creatorcontrib><creatorcontrib>LU QI</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><creatorcontrib>CARDOSO, Marly A</creatorcontrib><creatorcontrib>ACTION Study Team</creatorcontrib><creatorcontrib>for the ACTION Study Team</creatorcontrib><title>FTO Genotype, Vitamin D Status, and Weight Gain During Childhood</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged <10 years had complete genotypic and anthropometric data; 796 were followed up over a median 4.6 years. Baseline vitamin D insufficiency was defined as <75 nmol/L. We observed a 0.07 kg/m(2)/year increase in BMI and a 0.03 Z/year increase in BMI-for-age Z score per rs9939609 risk allele over follow-up (P = 0.01). Vitamin D status significantly modified FTO effects (P for interaction = 0.02). The rs9939609 risk allele was associated with a 0.05 Z/year increase in BMI-for-age Z score among vitamin D-insufficient children (P = 0.003), while no significant genetic effects were observed among vitamin D-sufficient children. Our data suggest that FTO rs9939609 affects child weight gain, and genotype effects are more pronounced among children with insufficient vitamin D levels.</description><subject>Alfacalcidol</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Calcifediol</subject><subject>Child</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Gene Expression Regulation, Developmental - physiology</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Genetic susceptibility</subject><subject>Genetics/Genomes/Proteomics/Metabolomics</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Obesity</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>Vitamin D</subject><subject>Vitamin D - metabolism</subject><subject>Weight</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt-L1DAQx4so3nr64D8gBREUrmd-3CbNi3is3ios7IOL-ham6aSbo032mla8_94U1ztXFpmHQOYz38xMvln2nJJzxrl8W1eUF5Qp8iCbUcVVwZn8_jCbEUJZQaWSJ9mTGK8JISLF4-yEXVBOOJ_PsvdXm3W-RB-G2x2e5V_dAJ3z-Yf8ywDDGM9y8HX-DV2zHfIlTJmxd77JF1vX1tsQ6qfZIwttxGf78zTbXH3cLD4Vq_Xy8-JyVRhByVAAihpsxZgoLdQMOCKppTSElVYyVRnFDAgCCgUwU1ohraoYF8pWQqYhT7N3v2V3Y9VhbdAPPbR617sO-lsdwOnDjHdb3YQfmitC5lwkgdd7gT7cjBgH3blosG3BYxijpheKSaoIm9CX_6DXYex9mk5TwaXgJRHynmqgRe28DeldM4nqSz4vyTyNxRJVHKEa9JiaDB6tS9cH_PkRPkWNnTNHC94cFCRmwJ9DA2OMulyu_tfMnjWhbbFBnf5rsT6qbfoQY4_2bt-U6Ml5enKenpyX2Bd_f9Ad-cdqCXi1ByAaaG0P3rh4z5WMcJH2-wsvHtrO</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>LOURENCO, Barbara H</creator><creator>LU QI</creator><creator>WILLETT, Walter C</creator><creator>CARDOSO, Marly A</creator><general>American Diabetes Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140201</creationdate><title>FTO Genotype, Vitamin D Status, and Weight Gain During Childhood</title><author>LOURENCO, Barbara H ; LU QI ; WILLETT, Walter C ; CARDOSO, Marly A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c610t-ae6dafb2268fad2a3ee0d77c028f729bc92ca60a9e6a2c8f67f9b2369fb67233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Alfacalcidol</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Calcifediol</topic><topic>Child</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Gene Expression Regulation, Developmental - physiology</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic research</topic><topic>Genetic susceptibility</topic><topic>Genetics/Genomes/Proteomics/Metabolomics</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Obesity</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>Vitamin D</topic><topic>Vitamin D - metabolism</topic><topic>Weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOURENCO, Barbara H</creatorcontrib><creatorcontrib>LU QI</creatorcontrib><creatorcontrib>WILLETT, Walter C</creatorcontrib><creatorcontrib>CARDOSO, Marly A</creatorcontrib><creatorcontrib>ACTION Study Team</creatorcontrib><creatorcontrib>for the ACTION Study Team</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOURENCO, Barbara H</au><au>LU QI</au><au>WILLETT, Walter C</au><au>CARDOSO, Marly A</au><aucorp>ACTION Study Team</aucorp><aucorp>for the ACTION Study Team</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>FTO Genotype, Vitamin D Status, and Weight Gain During Childhood</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>63</volume><issue>2</issue><spage>808</spage><epage>814</epage><pages>808-814</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><coden>DIAEAZ</coden><abstract>Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged <10 years had complete genotypic and anthropometric data; 796 were followed up over a median 4.6 years. Baseline vitamin D insufficiency was defined as <75 nmol/L. We observed a 0.07 kg/m(2)/year increase in BMI and a 0.03 Z/year increase in BMI-for-age Z score per rs9939609 risk allele over follow-up (P = 0.01). Vitamin D status significantly modified FTO effects (P for interaction = 0.02). The rs9939609 risk allele was associated with a 0.05 Z/year increase in BMI-for-age Z score among vitamin D-insufficient children (P = 0.003), while no significant genetic effects were observed among vitamin D-sufficient children. Our data suggest that FTO rs9939609 affects child weight gain, and genotype effects are more pronounced among children with insufficient vitamin D levels.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>24130335</pmid><doi>10.2337/db13-1290</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Alfacalcidol Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biological and medical sciences Body mass index Calcifediol Child Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene Expression Regulation, Developmental - physiology Genes Genetic aspects Genetic research Genetic susceptibility Genetics/Genomes/Proteomics/Metabolomics Genotype Genotype & phenotype Health aspects Humans Male Medical sciences Obesity Proteins - genetics Proteins - metabolism Vitamin D Vitamin D - metabolism Weight |
| title | FTO Genotype, Vitamin D Status, and Weight Gain During Childhood |
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