FTO Genotype, Vitamin D Status, and Weight Gain During Childhood

Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2014-02, Vol.63 (2), p.808-814
Hauptverfasser:	LOURENCO, Barbara H, LU QI, WILLETT, Walter C, CARDOSO, Marly A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alfacalcidol Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biological and medical sciences Body mass index Calcifediol Child Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gene Expression Regulation, Developmental - physiology Genes Genetic aspects Genetic research Genetic susceptibility Genetics/Genomes/Proteomics/Metabolomics Genotype Genotype & phenotype Health aspects Humans Male Medical sciences Obesity Proteins - genetics Proteins - metabolism Vitamin D Vitamin D - metabolism Weight
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Zusammenfassung:	Previous evidence suggests that variants in the fat mass and obesity-associated gene (FTO) affect adiposity in an age-dependent fashion in children, and nutritional factors may modify genotype effects. We assessed the effect of FTO rs9939609 on BMI and BMI-for-age Z score changes during childhood in a population-based longitudinal study in the Brazilian Amazon and investigated whether these effects were modified by vitamin D status, an important nutritional factor related to adiposity. At baseline, 1,088 children aged
ISSN:	0012-1797 1939-327X
DOI:	10.2337/db13-1290