Divergent Transcription: A Driving Force for New Gene Origination?

Divergent Transcription: A Driving Force for New Gene Origination?

The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.

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Bibliographische Detailangaben
Veröffentlicht in:Cell 2013-11, Vol.155 (5), p.990-996
Hauptverfasser: Wu, Xuebing, Sharp, Phillip A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
evolution
Evolution, Molecular
gene transcription
genes
Genome
Humans
mammals
Regulatory Sequences, Nucleic Acid
RNA, Untranslated - genetics
transcription
transcription (genetics)
Transcription, Genetic
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Beschreibung
Zusammenfassung:The mammalian genome is extensively transcribed, a large fraction of which is divergent transcription from promoters and enhancers that is tightly coupled with active gene transcription. Here, we propose that divergent transcription may shape the evolution of the genome by new gene origination.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2013.10.048