Absence of systemic toxicity changes following intramuscular administration of novel pSG2.HIVconsv DNA, ChAdV63.HIVconsv and MVA.HIVconsv vaccines to BALB/c mice

Highlights • Three novel vaccines were tested in 2 GLP toxicity studies in BALB/c mice. • Vaccines were vectored by DNA, simian adenovirus and modified vaccinia virus Ankara. • All 3 vaccines expressed the same conserved regions of HIV-1. • Intramuscular administration had no systemic toxicity. • Al...

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Veröffentlicht in:	Vaccine 2013-11, Vol.31 (47), p.5594-5601
Hauptverfasser:	Ondondo, Beatrice, Brennan, Caroline, Nicosia, Alfredo, Crome, Steven J, Hanke, Tomáš
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome Adenoviridae - genetics AIDS AIDS Vaccines - administration & dosage AIDS Vaccines - adverse effects Allergy and Immunology Animals Anticoagulants antigens Antiretroviral agents Applied microbiology Biological and medical sciences blood chemistry Body weight chimerism Chimpanzee adenovirus clinical trials Conserved regions of HIV-1 Deoxyribonucleic acid DNA Drug Carriers Drug-Related Side Effects and Adverse Reactions - epidemiology Drug-Related Side Effects and Adverse Reactions - pathology Female Females food consumption Fundamental and applied biological sciences. Psychology health services Hematology HIV infections HIV-1 - immunology HIV-1 vaccines Human immunodeficiency virus 1 Injection Injections, Intramuscular intramuscular injection Male Mice Mice, Inbred BALB C Microbiology Miscellaneous Modified vaccinia virus Ankara (MVA) patients Plasmid DNA plasmids Pre-clinical toxicity proteome Studies T-lymphocytes tissue weight Toxicity Triglycerides United Kingdom Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - adverse effects Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccinia virus - genetics Virology viruses
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Beschreibung
Zusammenfassung:	Highlights • Three novel vaccines were tested in 2 GLP toxicity studies in BALB/c mice. • Vaccines were vectored by DNA, simian adenovirus and modified vaccinia virus Ankara. • All 3 vaccines expressed the same conserved regions of HIV-1. • Intramuscular administration had no systemic toxicity. • All changes were consistent with i.m. delivery and immune response induction.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2013.06.068