The Effect of Trapidil and Bevacizumab on Tracheal Anastomotic Wound Healing

ABSTRACT Background Although bevacizumab has deleterious effects on the healing of colonic anastomoses, trapidil improves wound healing of colonic and tracheal anastomoses. Objective We aimed to assess the effects of bevacizumab and trapidil on wound healing after tracheal transection. Materials and methods We evaluated 35 rats divided in 5 groups: bevacizumab (Group I, n = 7), trapidil (Group II, n = 7), trapidil + bevacizumab (Group III, n = 7), controls (Group IV, n = 7), and sham (Group V, n = 7). Anastomotic healing was assessed by measurement of bursting pressure and inflammation score at the anastomotic region on the seventh day. Results The bursting pressures of Group II, Group III, and Group V were significantly higher than controls ( P = 0.001, P = 0.033, and P = 0.035, respectively). Fibrosis was significantly high in the sham group when compared with the other four groups ( P = 0.047). Conclusions Although bevacizumab seems to impair anastomotic healing, trapidil can be suggested to improve tracheal anastomoses.