Mammalian Cells with Altered Forms of RNA Polymerase II

Mutants of Chinese hamster ovary cells that are resistant to α -amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to α -amanitin. These results indicate that mutation to α -amanitin resistance involves...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1972-11, Vol.69 (11), p.3119-3123
Hauptverfasser:	Chan, V. L., Whitmore, G. F., Siminovitch, Louis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences: Cell Biology Cell culture techniques Cell growth Cell Line Cell lines Cells CHO cells Chromatography, DEAE-Cellulose Cricetinae DNA DNA - metabolism DNA-Directed RNA Polymerases - analysis DNA-Directed RNA Polymerases - antagonists & inhibitors DNA-Directed RNA Polymerases - isolation & purification Drug Resistance Enzymes Female Mycotoxins - pharmacology Ovaries Ovary - drug effects Ovary - enzymology RNA Somatic cells Templates, Genetic Tritium Uracil Nucleotides - metabolism
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