Higher Rates of Decline for Women and Apolipoprotein E ε4 Carriers

Higher Rates of Decline for Women and Apolipoprotein E ε4 Carriers

This study assesses the risk of being female in addition to the well-known factors of age and apolipoprotein E ε4 status in the development and progression of Alzheimer disease based on longitudinal brain atrophy, cognitive decline, and CSF markers. APOE ε4 accelerated rates of decline, especially i...

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Veröffentlicht in:American journal of neuroradiology : AJNR 2013-12, Vol.34 (12), p.2287-2293
Hauptverfasser: Holland, D., Desikan, R.S., Dale, A.M., McEvoy, L.K.
Format: Artikel
Sprache:eng
Schlagworte:
Brain
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Zusammenfassung:This study assesses the risk of being female in addition to the well-known factors of age and apolipoprotein E ε4 status in the development and progression of Alzheimer disease based on longitudinal brain atrophy, cognitive decline, and CSF markers. APOE ε4 accelerated rates of decline, especially in women. The gender effect was at least as important as APOE ε4 status and showed weaker relationships to CSF markers.
ISSN:0195-6108
1936-959X
DOI:10.3174/ajnr.A3601