OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells

Highlights • Inhibition of 5-Lox induces apoptosis in prostate cancer cells which is prevented by 5-oxoETE. • Inhibition of PLC-beta neutralizes the apoptosis-preventing effects of 5-oxoETE. • Prostate tumors and prostate cancer cells express OXER1, a G protein-coupled 5-oxoETE receptor. • DAG, a pr...

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Veröffentlicht in:	Cancer letters 2013-08, Vol.336 (1), p.185-195
Hauptverfasser:	Sarveswaran, Sivalokanathan, Ghosh, Jagadananda
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Lipoxygenase 5-OxoETE Androgens Apoptosis Arachidonate 5-Lipoxygenase - metabolism Cell Line, Tumor Cell Survival Estrenes - pharmacology Hematology, Oncology and Palliative Medicine Humans Kinases Male Medical research Metabolites OXER1 Phospholipase C beta - metabolism PKC-epsilon PLC-beta Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Protein Kinase C-epsilon - metabolism Pyrrolidinones - pharmacology Receptors, Eicosanoid - metabolism Signal Transduction Time Factors
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Zusammenfassung:	Highlights • Inhibition of 5-Lox induces apoptosis in prostate cancer cells which is prevented by 5-oxoETE. • Inhibition of PLC-beta neutralizes the apoptosis-preventing effects of 5-oxoETE. • Prostate tumors and prostate cancer cells express OXER1, a G protein-coupled 5-oxoETE receptor. • DAG, a product of PLC-beta, prevents 5-Lox inhibition-induced apoptosis. • OXER1, PLC-beta and PLCε exist as a multienzyme complex which is disrupted by inhibition of 5-Lox.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.04.027