Mechanisms underlying obesity resistance associated with high spontaneous physical activity

Highlights • OX1R and DA1R antagonists reduced OXA-induced SPA more effectively in lean rats. • OXA increased arousal equally in lean and obese rodents. • OR rats ran more and wheel running was directly related to 24-h SPA levels.

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Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2014-01, Vol.256, p.91-100
Hauptverfasser:	Teske, J.A, Billington, C.J, Kotz, C.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Benzazepines - pharmacology Benzoxazoles - pharmacology Biological and medical sciences Body Weight - drug effects Dopamine Antagonists - pharmacology Eating - drug effects Electromyography Eye Movements - drug effects Fundamental and applied biological sciences. Psychology Hypothalamus - drug effects Hypothalamus - physiology Intracellular Signaling Peptides and Proteins - pharmacology Male Medical sciences Metabolic diseases Motor Activity - drug effects Motor Activity - physiology Neurology Neuropeptides - pharmacology Obesity Obesity - physiopathology Orexin Receptor Antagonists Orexins Rats Rats, Sprague-Dawley Sleep - drug effects Substantia Nigra - drug effects Substantia Nigra - physiology Urea - analogs & derivatives Urea - pharmacology Vertebrates: nervous system and sense organs Wakefulness - drug effects
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Beschreibung
Zusammenfassung:	Highlights • OX1R and DA1R antagonists reduced OXA-induced SPA more effectively in lean rats. • OXA increased arousal equally in lean and obese rodents. • OR rats ran more and wheel running was directly related to 24-h SPA levels.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.10.028