Hyperoxia during one lung ventilation: Inflammatory and oxidative responses

Background It is common practice during one lung ventilation (OLV) to use 100% oxygen, although this may cause hyperoxia‐ and oxidative stress‐related lung injury. We hypothesized that lower oxygen (FiO2) during OLV will result in less inflammatory and oxidative lung injury and improved lung functio...

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Veröffentlicht in:	Pediatric pulmonology 2012-10, Vol.47 (10), p.979-986
Hauptverfasser:	Olivant Fisher, Alicia, Husain, Kamran, Wolfson, Marla R., Hubert, Terrence L., Rodriguez, Elena, Shaffer, Thomas H., Theroux, Mary C.
Format:	Artikel
Sprache:	eng
Schlagworte:	acute lung injury Acute Lung Injury - enzymology Acute Lung Injury - etiology Acute Lung Injury - physiopathology Animals Biological and medical sciences Carbon Dioxide - blood Cytokines - blood General aspects Hyperoxia - blood Hyperoxia - etiology Hyperoxia - physiopathology Inflammation - blood Inflammation - physiopathology Lung - enzymology Lung - physiology Medical sciences One-Lung Ventilation - adverse effects Oxidative Stress Oxygen - adverse effects Peroxidase - analysis Pneumology Protein Carbonylation - physiology single-lung ventilation Superoxide Dismutase - analysis Swine thoracic surgery
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Zusammenfassung:	Background It is common practice during one lung ventilation (OLV) to use 100% oxygen, although this may cause hyperoxia‐ and oxidative stress‐related lung injury. We hypothesized that lower oxygen (FiO2) during OLV will result in less inflammatory and oxidative lung injury and improved lung function. Methods Twenty pigs (8.88 ± 0.84 kg; 38 ± 4.6 days) were assigned to either the hyperoxia group (n = 10; FiO2 = 100%) or the normoxia group (n = 10; FiO2
ISSN:	8755-6863 1099-0496
DOI:	10.1002/ppul.22517