EGF receptor trafficking: consequences for signaling and cancer

Highlights • EGF receptor endocytic traffic can regulate signaling and cell survival. • Signaling from activated EGFR occurs at the endosome as well as the cell surface. • Endocytosis can have positive and negative effects on signaling and tumorigenesis. • EGFR traffic promoted by antineoplastic the...

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Veröffentlicht in:	Trends in cell biology 2014-01, Vol.24 (1), p.26-34
Hauptverfasser:	Tomas, Alejandra, Futter, Clare E, Eden, Emily R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology antineoplastic therapy Endocytosis epidermal growth factor receptor (EGFR) ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - metabolism GRB2 Adaptor Protein - metabolism Humans Multivesicular Bodies - metabolism Mutation Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology oncogenes Pathology Protein Transport Proteolysis Review Signal Transduction trafficking Ubiquitination
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